Modulation of 5-HT receptor subtype-mediated behaviours by corticosterone
| Autor: | Bernard W.M.M. Peeters, Chris L.E. Broekkamp, Hemmie H.G. Berendsen, Robert C.H. Kester |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Serotonergic Open field chemistry.chemical_compound Postsynaptic potential Corticosterone Internal medicine medicine Animals Rats Wistar Receptor 5-HT receptor Pharmacology MK-212 8-Hydroxy-2-(di-n-propylamino)tetralin Behavior Animal Amphetamines Rats Serotonin Receptor Agonists Endocrinology chemistry Mineralocorticoid Pyrazines Receptors Serotonin Locomotion |
| Zdroj: | European journal of pharmacology. 308(2) |
| ISSN: | 0014-2999 |
| Popis: | Malfunction of the serotonergic system and dysregulation of the hypothalamo-pituitary-adrenocortical axis have been implicated in the pathophysiology of depression. Several studies provide evidence for reciprocal influences between glucocorticoids and 5-HT receptors. The effect of repeated treatment with a high dose of corticosterone (50 mg/kg s.c. twice daily for 4 days) on 5-HT receptor subtype-mediated behaviours was studied. It was found that in rats that were repeatedly treated with corticosterone the number of 2-chloro-6-(1-piperazinyl)pyrazine HCl (MK 212)-induced, 5-HT2C receptor-mediated penile erections were reduced, whereas both MK 212 and (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced 5-HT2A receptor-mediated head shakes were increased. The (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)-induced lower lip retraction mediated by presynaptic 5-HT1A receptors was unchanged, whereas the open field activity induced by 8-OH-DPAT was enhanced in corticosterone pretreated rats. These changes in 5-HT receptor subtype-mediated behaviours were not seen after a single injection with corticosterone given 24 h or 5 days before. The results suggest that 5-HT2A, 5-HT2C and postsynaptic 5-HT1A receptor-mediated behaviour can be modulated by repeated treatment with a high dose of corticosterone. |
| Databáze: | OpenAIRE |
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