Sustained consumption of cocoa-based dark chocolate enhances seizure-like events in the mouse hippocampus
| Autor: | Maureen Cabatic, Bastian Auer, Ana Cicvaric, Jiaye Yang, Tanja Bulat, Daniel Bormann, Ivan Milenkovic, Francisco J. Monje, Radoslav Milicevic |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Excessive caffeine intake Hippocampus Dark chocolate Hippocampal formation Biology Epileptogenesis Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine food Seizures Animals Humans Chocolate Neurons Cacao Dentate gyrus food and beverages Population spike General Medicine Receptors GABA-A food.food Mice Inbred C57BL 030104 developmental biology chemistry Caffeine Neuroscience 030217 neurology & neurosurgery Food Science |
| Zdroj: | Food & Function. 9:1532-1544 |
| ISSN: | 2042-650X 2042-6496 |
| DOI: | 10.1039/c7fo01668a |
| Popis: | While the consumption of caffeine and cocoa has been associated with a variety of health benefits to humans, some authors have proposed that excessive caffeine intake may increase the frequency of epileptic seizures in humans and reduce the efficiency of antiepileptic drugs. Little is known, however, about the proconvulsant potential of the sustained, excessive intake of cocoa on hippocampal neural circuits. Using the mouse as an experimental model, we examined the effects of the chronic consumption of food enriched in cocoa-based dark chocolate on motor and mood-related behaviours as well as on the excitability properties of hippocampal neurons. Cocoa food enrichment did not affect body weights or mood-related behaviours but rather promoted general locomotion and improved motor coordination. However, ex vivo electrophysiological analysis revealed a significant enhancement in seizure-like population spike bursting at the neurogenic dentate gyrus, which was paralleled by a significant reduction in the levels of GABA-α1 receptors thus suggesting that an excessive dietary intake of cocoa-enriched food might alter some of the synaptic elements involved in epileptogenesis. These data invite further multidisciplinary research aiming to elucidate the potential deleterious effects of chocolate abuse on behaviour and brain hyperexcitability. |
| Databáze: | OpenAIRE |
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