Antioxidant status and nitric oxide in the malnutrition syndrome kwashiorkor
| Autor: | Katja Becker, Catharina C. Böhme, Stephan Gromer, Matthias Funk, R. Heiner Schirmer, Anke Fechner |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Antioxidant Adolescent Bilirubin medicine.medical_treatment medicine.disease_cause Nitric Oxide Antioxidants Nitric oxide chemistry.chemical_compound Internal medicine medicine Humans Longitudinal Studies business.industry Kwashiorkor Albumin Glutathione Middle Aged medicine.disease Endocrinology chemistry Biochemistry Pediatrics Perinatology and Child Health Uric acid Female business Oxidative stress |
| Zdroj: | Pediatric research. 49(2) |
| ISSN: | 0031-3998 |
| Popis: | The pathophysiology of kwashiorkor, a severe edematous manifestation of malnutrition, is still poorly understood. The syndrome is, however, known to be associated with alterations in redox metabolism. To further elucidate the role of oxidative stress in kwashiorkor, we carried out a longitudinal study on the major blood antioxidants at the St. Joseph's Hospital, Jirapa, Ghana. All kwashiorkor patients (K) were followed up for 20 d. In comparison with local healthy controls (C), the plasma total antioxidant status was reduced to less than 50% in the patients (C, 0.87 +/- 0.21 mM; K, 0.40 +/- 0.20 mM; p0.001). Similarly, the major plasma antioxidant albumin (C, 40.9 +/- 2.5 g/L; K, 19.1 +/- 7.4 g/L; p0.001) and erythrocyte glutathione (C, 2.39 +/- 0.28 mM; K, 1.01 +/- 0.33; p0.001) were decreased, whereas the levels of bilirubin and uric acid were not significantly altered. Nitrite and nitrate were found to be increased by a factor of 2 in kwashiorkor (C, 120 +/- 46 microM; K, 235 +/- 107 microM; p0.001). Over the observation period, the trends of albumin and glutathione levels were related to clinical outcome. These concentrations rose in patients who recovered and fell in patients who did not. Our study strongly supports the hypothesis that oxidative and nitrosative stress play a role in the pathophysiology of edematous malnutrition. Prophylactic and therapeutic strategies should aim at the careful correction of the reduced antioxidant status of the patients. |
| Databáze: | OpenAIRE |
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