Effects of an EE/CA compared with EE/CA-metformin on serum ADMA levels in women with polycystic ovary syndrome
| Autor: | Giray Bozkaya, Ahmet Alacacioglu, Cüneyt Eftal Taner, Ismail Sari, Ayse Gul Kebapcilar, Arif Yuksel, Oktay Bilgir, Levent Kebapcilar |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases medicine.medical_treatment cyproterone acetate chemistry.chemical_compound Insulin resistance Ethinylestradiol Internal medicine medicine medicine.diagnostic_test business.industry Insulin pcos nutritional and metabolic diseases Cyproterone acetate General Medicine medicine.disease Polycystic ovary Metformin Endocrinology chemistry Homeostatic model assessment ethinylestradiol Medicine metformin Lipid profile business adma medicine.drug |
| Zdroj: | Open Medicine, Vol 4, Iss 4, Pp 423-427 (2009) |
| ISSN: | 2391-5463 |
| DOI: | 10.2478/s11536-009-0074-x |
| Popis: | To determine the effects of EE/CA (Ethinylestradiol/ Cyproterone Acetate) and EE/CA-metformin treatments on the asymmetric dimethylarginine (ADMA) levels in women with PCOS (Polycystic Ovary Syndrome). Among 43 patients diagnosed with PCOS, one study arm (n=22) was administered (35 µg EE, 2mg CA) and the other (n=21) was administered (35 µg EE, 2mg CA plus 1700mg metformin). Serum ADMA, lipid profile, androgens, insulin, and HOMA-IR (Homeostatic Model Assessment of Insulin Resistance ) values were assessed prior to treatment and after 3 months of therapy. A significant reduction in ADMA levels relative to pre-treatment in the EE/CA+metformin group (1.2±0.4 vs 0.95±0.4, p=0.016) compared to the EE/CA group (1.0±0.5 vs 1.03±0.4, p >0.05). Andogens, insulin and HOMA-IR levels decreased in both treatment groups. All lipid profiles significantly improved in-group EE/CA+metformin while no significant decrease was observed in TG and HDL-cholesterol levels in EE/CA group. Post-treatment levels of HDL-C levels correlated significantly with the reducing ADMA levels in the EE/CA+metformin group (P=0.005, r= 0.602). Adding metformin to EE/CA therapy in PCOS may beneficial endothelium effects associated with reduction of ADMA levels. |
| Databáze: | OpenAIRE |
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