Effectiveness of Short-Term Olanzapine in Patients With Bipolar I Disorder, With or Without Comorbidity With Substance Use Disorder
| Autor: | Sani, Gabriele, Kotzalidis, Giorgio, Paul, Vohringer, Pucci, Daniela, Simonetti, Alessio, Giovanni, Manfredi, Savoja, Valeria, Tamorri, STEFANO MARIA, Mazzarini, Lorenzo, Pacchiarotti, Isabella, Telesforo, CARLA LUDOVICA, Ferracuti, Stefano, Brugnoli, Roberto, Ambrosi, Elisa, Caloro, Matteo, DEL CASALE, Antonio, Koukopoulos, Alexia, Vergne, Derick E., Girardi, Paolo, Nassir Ghaemi, S. |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Olanzapine medicine.medical_specialty Bipolar Disorder Time Factors Bipolar I disorder Substance-Related Disorders olanzapine Craving behavioral disciplines and activities Benzodiazepines Young Adult mental disorders medicine Humans Pharmacology (medical) Prospective Studies Bipolar disorder Young adult Prospective cohort study Psychiatry health care economics and organizations substance use disorder craving Middle Aged medicine.disease Comorbidity humanities Hospitalization Substance abuse comorbidity Psychiatry and Mental health Logistic Models Treatment Outcome Diagnosis Dual (Psychiatry) Case-Control Studies bipolar disorder type i behavior and behavior mechanisms Female medicine.symptom Psychology Antipsychotic Agents Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Clinical Psychopharmacology. 33:231-235 |
| ISSN: | 0271-0749 |
| Popis: | Prognosis of comorbid bipolar disorder (BD) and drug abuse is poor. We assessed the efficacy of olanzapine in manic or mixed BD patients, with (SUD) or without (N-SUD) comorbidity with substance use disorder (SUD) and its effect on drug abuse, days of abuse, and craving.Eighty patients with BD-I (40 SUD) were hospitalized for a manic or mixed episode and received add-on olanzapine. Assessments were conducted at admission, discharge, and 4 and 8 weeks after discharge. Primary outcome was the proportion of responders and remitters in each group. We used a logistic regression model to adjust for possible confounders. We assessed craving and drug-abuse days with a visual analog scale and the Timeline Follow-Back.SUD and N-SUD were similar on response and remission, adjusted for sex, age, years ill, age at first episode, first episode depressive, number of hospitalizations, and duration of hospitalization (odds ratio, 1.09; 95% confidence interval, 1.02-2.29). Mood rating scores dropped significantly from baseline to end point in both groups. Timeline follow-back decreased in SUD from 22.5 to 7.3 at 8 weeks postdischarge, whereas craving dropped from 8.3 to 5.1 (P0.03).The effectiveness of short-term olanzapine in BD-I mania or mixed mania did not differ according to SUD comorbidity. Treatment was followed by less substance use/abuse and craving in comorbid bipolar-SUD patients. |
| Databáze: | OpenAIRE |
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