| Autor: |
Mauro Delorenzi, Sabine Tejpar, Fred T. Bosman, Arnaud D. Roth, Iris M. Simon, Justin Guinney, Peter Gibbs, Stephen McLaughlin, Ian T. Jones, Peter L. Molloy, Chris Love, Robert N. Jorissen, Oliver M. Sieber, Pratyaksha Wirapati, Edoardo Missiaglia, David Barras |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1078-0432.22466433.v1 |
| Popis: |
Figure S1. Principal component analysis and hierarchical clustering of the 218 BRAF mutant patient cohort;Figure S2: Gene-wise and patient-wise biclustering heatmap of the 218 BRAF mutant patient cohort and comparison of BRAF mutant subtypes obtained with and without adjusting for microsatellite instability status;Figure S3: Geneset enrichment analysis (GSEA) of BM subtypes for the four most enriched signature of the Hallmark collection and gene overlap between signatures and BM-specific genes;Figure S4: Patient-level single sample geneset enrichment analysis (ssGSEA) between BM subtypes, double BRAF wild-type KRAS wild-type (WT2) and KRAS mutant patients for the hallmark signature collection;Figure S5: Patient-averaged single sample geneset enrichment analysis (ssGSEA) between BM subtypes, double BRAF wild-type KRAS wild-type (WT2) and KRAS mutant patients for the hallmark signature collection;Figure S6: Gene overlap between selected sets of gene signatures used in this study;Figure S7: Immune landscape of the BM subtypes;Figure S8: Methylation analysis of BM subtypes using TCGA data;Figure S9: Survival and clinical characteristics of the BRAF mutant patients enrolled in the survival analysis;Figure S10: Performance of the generalized model used to classify patients into BM1 and BM2 subtypes;Figure S11: Drug responses of colorectal cancer cell lines classified into BM1 and BM2. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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