Influence of control selection in nested case-control studies: the example of exposure to antiretroviral treatment (ART) and the risk of myocardial infarction (MI) in the French Hospital Database on HIV (FHDH-ANRS CO4)
| Autor: | Dominique Costagliola, M. Guiguet, Murielle Mary-Krause, Sophie Grabar, B. Ename |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Matching (statistics) Time Factors Databases Factual Epidemiology Myocardial Infarction Human immunodeficiency virus (HIV) HIV Infections computer.software_genre medicine.disease_cause Bias Risk Factors medicine Humans Pharmacology (medical) Myocardial infarction Database business.industry Incidence Age Factors Sampling (statistics) Confounding Factors Epidemiologic HIV Protease Inhibitors medicine.disease Control selection Case-Control Studies Cohort Nested case-control study France Epidemiologic Methods business computer Cohort study |
| Zdroj: | Pharmacoepidemiology and Drug Safety. 17:468-474 |
| ISSN: | 1099-1557 1053-8569 |
| Popis: | Purpose Soon after availability of protease inhibitors (PIs), a duration-related effect relationship between PI and myocardial infarction (MI) was shown. New antiretroviral treatments (ARTs) have allowed more individualized regimens. To study their influence established risk factors of MI and additional therapeutic options such as lipid-lowering drugs will have to be taken into account. A nested case-control is an interesting alternative raising the choice of controls. With the previous full cohort analysis as reference, we investigated the influence of control selection in nested case-control studies sampled in this cohort by testing nine sampling scenarios. Methods During the period 1996–1999, 49 MI occurred among male patients exposed to PI and followed-up in the French Hospital Database on HIV (FHDH-ANRS CO4). For each case, controls were selected using incidence-density sampling. The influence of additional matching criteria was tested. Random sampling and analysis was repeated 100 times with varying control-case ratios. Results When controls were randomly selected among patients of the same age who were free of MI at the date MI was diagnosed in the case, we observed a duration-related effect relationship between PI and MI in agreement with the results of the full cohort analysis. The use of four controls per case was sufficient. Estimates obtained with simple sampling were more precise than those obtained when controls were also matched for year of enrolment, initial CD4 cell count and HIV transmission group. Conclusion To study ARTs as MI risk factors, nested case-control using incidence-density sampling without additional matching is one appropriate option. Copyright © 2008 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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