Flavin-mediated photo-oxidation for the detection of mitochondrial flavins
| Autor: | Dong Nam Lee, Jae Hong Lee, Jong-In Hong, Chulhun Kang, Eun-Jin Kim, Jong Seung Kim |
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| Rok vydání: | 2016 |
| Předmět: |
genetic structures
Dinitrocresols High selectivity Analytical chemistry Electron Flavin group 010402 general chemistry Photochemistry 01 natural sciences Hippocampus Catalysis Cell Line Tumor Materials Chemistry Molecule Moiety Animals Humans Fluorescent Dyes Molecular Structure 010405 organic chemistry Chemistry Metals and Alloys General Chemistry Photochemical Processes 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Mitochondria Rats Ceramics and Composites sense organs Mitochondrial localization Oxidation-Reduction |
| Zdroj: | Chemical communications (Cambridge, England). 52(92) |
| ISSN: | 1364-548X |
| Popis: | We report a new approach for the detection of mitochondrial flavins through photo-oxidation of a probe molecule. Probe 1 showed high brightness (e × Φf = 6.50 × 103 M−1 cm−1) at long wavelengths (maximum emission wavelength, λmax = 600 nm) upon photo-oxidation, assisted by the strong electron accepting ability of the isoalloxazine moiety in flavins. Probe 1 also exhibited high selectivity for flavins over various biological oxidants, remarkable photo-stability, and mitochondrial localization. |
| Databáze: | OpenAIRE |
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