Continuous infusion of 5-azacytidine as induction for acute nonlymphocytic leukemia in patients with previous exposure to 5-azacytidine
| Autor: | Paul S. Gaynon, E S Baum |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Adolescent Continuous infusion Severe myelosuppression Azacitidine Gastroenterology Internal medicine medicine Humans In patient Infusions Parenteral Child Clinical Trials as Topic business.industry Infant General Medicine medicine.disease Leukemia Diarrhea Leukemia Myeloid Acute Oncology Child Preschool Immunology Female medicine.symptom business Multiagent chemotherapy medicine.drug |
| Zdroj: | Oncology. 40(3) |
| ISSN: | 0030-2414 |
| Popis: | 5 children with acute nonlymphocytic leukemia in relapse who had received 5-azacytidine as a part of previous multiagent chemotherapy received continuous infusion of 5-azacytidine, 150-200 mg/m2/day, for 5-7 days every 2 weeks. 2 achieved remission marrows with good peripheral counts (duration 1 and 3 months). 1 achieved a transient remission marrow but remained pancytopenic and 1 achieved reduction from 91% blasts to 18% blasts in the marrow. Principal toxicities were severe myelosuppression, diarrhea, and phlebitis. |
| Databáze: | OpenAIRE |
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