Prion-like propagation of α-synuclein in the gut-brain axis
Autor: | Qian-Hang Shao, Ying Chen, Yu-He Yuan, Nai-Hong Chen |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Nervous system Movement disorders Parkinson's disease Prions Gut–brain axis Substantia nigra Enteric Nervous System 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Degenerative disease Parkinsonian Disorders Medicine Animals Humans Alpha-synuclein business.industry General Neuroscience Brain medicine.disease nervous system diseases 030104 developmental biology medicine.anatomical_structure nervous system chemistry alpha-Synuclein Enteric nervous system medicine.symptom business Neuroscience 030217 neurology & neurosurgery |
Zdroj: | Brain research bulletin. 140 |
ISSN: | 1873-2747 |
Popis: | Parkinson's disease (PD) is a progressive degenerative disease of the nervous system, which is characterized by movement disorders, such as static tremor, rigidity, and bradykinesia in advanced patients. Gastrointestinal (GI) dysfunction, such as gastric dysmotility, constipation, and anorectic dysfunction, is common non-motor symptom in the early stage of PD. The progression of PD includes the degenerative loss of dopaminergic (DA) neurons and aggregation of α-synuclein in the substantia nigra (SN). Interestingly, both of them are also present in the enteric nervous system (ENS) of PD patients. In this review, we describe the relationship between non-motor symptoms particularly GI dysfunction and the pathogenesis of PD, aiming to show the powerful evidences about the prion-like propagation of α-synuclein and support the hypothesis of gut-brain axis in PD. We then summarize the mechanism of the gut-brain axis and confirm α-synuclein as a potential target for drug design or new clinical treatment. |
Databáze: | OpenAIRE |
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