The Prevalence of Hepatitis E Virus Infections among Swine, Swine Farmers and the General Population in Guangdong Province, China

Autor: Chumin Liang, Heng Wang, Lifang Wang, Honglang Gu, Guihong Zhang, Fangxiao Ji, Shuo Su, Shengchao Deng, Huanbin Liang
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Veterinary medicine
Epidemiology
Swine
animal diseases
viruses
Veterinary Microbiology
lcsh:Medicine
medicine.disease_cause
Hepatitis
Hepatitis E virus
Antibody Specificity
Genotype
Odds Ratio
Prevalence
Bile
Animal Husbandry
lcsh:Science
Phylogeny
Swine Diseases
education.field_of_study
Multidisciplinary
Geography
virus diseases
Middle Aged
Hepatitis E
Medicine
Infectious diseases
RNA
Viral
Livestock
Female
Veterinary Pathology
Research Article
Adult
medicine.medical_specialty
China
Population
Molecular Sequence Data
Viral diseases
Biology
Infectious Disease Epidemiology
Veterinary Epidemiology
Diagnostic Medicine
medicine
Seroprevalence
Animals
Humans
Hepatitis Antibodies
education
Population Biology
Base Sequence
business.industry
lcsh:R
Odds ratio
medicine.disease
digestive system diseases
Immunoglobulin G
lcsh:Q
Veterinary Science
business
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e88106 (2014)
ISSN: 1932-6203
Popis: Hepatitis E virus (HEV) infection is widespread in China, but few studies have been carried out in Guangdong Province. This study aimed to characterize the prevalence of HEV infections among swine, swine farmers and the general population in Guangdong Province. We conducted an epidemiological study that included swine, swine farmers and health examination attendees in Guangdong from 2011 to 2013. The overall seroprevalence of anti-HEV antibodies in swine was 64.7%. The results revealed that growing pigs, sows and boars (OR ranges from 3.5 to 21.5) have a higher risk than nursery pigs. HEV RNA in swine bile showed that HEV is epidemic in swine in the Pearl River Delta, with the highest prevalence of 22.73% in Foshan. Some genomes of HEV strains from each district were sequenced. Phylogenetic analysis of partial open reading frame 2 (ORF2) shows that they belong to genotype IV and are most closely related to isolates from China. In total, 307 participants were enrolled in the study, including 114 swine farmers and 193 attendees from hospitals. IgG anti-HEV was detected in 48.25% of swine farmers and in 38.34% of the general population. Seroprevalence rates were almost stratified by age, with a higher positive rate for males compared to females across all age groups. Women on swine farms appeared to have a lower risk of infection compared to the general population, revealing that the risk factors for HEV infection are not unique. The results suggested that there were other risk factors for HEV infection. HEV infection is prevalent in Guangdong, but due to the small sample sizes, more investigations are needed to assess the potential impact of HEV infection, and many additional risk factors should be considered.
Databáze: OpenAIRE
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