Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P
| Autor: | Yasuhide Lee, C.J. Hillyard, S. Girgis, I. MacIntyre, Masaya Tohyama, Piers C. Emson, Kenji Takami, Yuriko Kawai |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Calcitonin
Male medicine.medical_specialty Calcitonin Gene-Related Peptide Immunocytochemistry Thyroid Gland Fluorescent Antibody Technique Nerve Tissue Proteins Substance P Calcitonin gene-related peptide Biology chemistry.chemical_compound Ganglia Spinal Internal medicine medicine Animals Peripheral Nerves Ganglia Autonomic General Neuroscience Stomach Thyroid Rats medicine.anatomical_structure Endocrinology Sensory Ganglion chemistry Peripheral nervous system Pterygopalatine ganglion hormones hormone substitutes and hormone antagonists |
| Zdroj: | Neuroscience. 15:1227-1237 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/0306-4522(85)90265-9 |
| Popis: | This immunocytochemical study, using a double-staining method, showed that calcitonin gene-related peptide-like immunoreactive structures are widely distributed in the peripheral nervous system and that many of them coexist with substance P-like immunoreactive structures in single sensory ganglion cells. Neurons positive for calcitonin gene-related peptide but negative for substance P were detected in sensory ganglia. These cells were large (about 30-45 micron in diameter); these primary sensory neurons containing calcitonin gene-related peptide can probably act independently of substance P. There were neurons containing calcitonin gene-related peptide without substance P in the pterygopalatine ganglion, although these cells were less numerous than in the sensory ganglia. In consecutive sections, calcitonin gene-related peptide-like structures occurred in thyroid parafollicular cells, which also contain calcitonin. This suggested that messenger RNA for producing calcitonin gene-related peptide is also present in the thyroid, and like calcitonin, calcitonin gene-related peptide may have a peripheral physiological role. |
| Databáze: | OpenAIRE |
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