Sleep apnea is associated with bronchial inflammation and continuous positive airway pressure-induced airway hyperresponsiveness
| Autor: | Eliane Rossini, Jean-Louis Pépin, Michèle Fior-Gozlan, Mireille Henry, Patrick Levy, Isabelle Pin, Daniel Seigneurin, Gilles Devouassoux |
|---|---|
| Přispěvatelé: | laboratoire du sommeil, CHU Grenoble, Service des maladies respiratoires, Hospices Civils de Lyon (HCL), laboratoire HP2, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cytologie, Vesin, Aurélien |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
MESH: Continuous Positive Airway Pressure Neutrophils medicine.medical_treatment MESH: Sleep Apnea Obstructive MESH: Neutrophils Systemic inflammation Gastroenterology Bronchoconstrictor Agents 0302 clinical medicine MESH: Sputum MESH: Respiratory Mucosa Immunology and Allergy Continuous positive airway pressure Methacholine Chloride COPD Sleep Apnea Obstructive MESH: Bronchitis MESH: Middle Aged Continuous Positive Airway Pressure MESH: Bronchoconstrictor Agents Sleep apnea MESH: Bronchi Middle Aged respiratory system 3. Good health Exhalation Anesthesia Female medicine.symptom Bronchial Hyperreactivity Adult medicine.medical_specialty Immunology Positive pressure Bronchi Respiratory Mucosa Nitric Oxide 03 medical and health sciences MESH: Exhalation Internal medicine MESH: Methacholine Chloride medicine Humans Bronchitis MESH: Humans business.industry Interleukin-8 Sputum MESH: Bronchial Hyperreactivity MESH: Adult medicine.disease MESH: Male respiratory tract diseases MESH: Interleukin-8 Obstructive sleep apnea 030228 respiratory system Apnea–hypopnea index [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie MESH: Nitric Oxide [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Airway business MESH: Female 030217 neurology & neurosurgery |
| Zdroj: | Journal of Allergy and Clinical Immunology Journal of Allergy and Clinical Immunology, Elsevier, 2007, 119 (3), pp.597-603. ⟨10.1016/j.jaci.2006.11.638⟩ |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/j.jaci.2006.11.638⟩ |
| Popis: | International audience; BACKGROUND: Obstructive sleep apnea syndrome (OSA) is associated with systemic and upper airway inflammation. Pharyngeal inflammation has a potential role in upper airway collapse, whereas systemic inflammation relates to cardiovascular morbidity. However, the presence of an inflammatory involvement of lower airway has been poorly investigated. OBJECTIVE: The aim of the study was to demonstrate an inflammatory process at the bronchial level in patients with OSA and to analyze effects of continuous positive airway pressure (CPAP) application and humidification on bronchial mucosa. METHODS: The study was conducted by using sequential induced sputum for cell analysis and IL-8 production, nitric oxide exhalation measurement, and methacholine challenge before and after CPAP. RESULTS: Bronchial neutrophilia and a high IL-8 concentration were observed in untreated OSA compared with controls (75% +/- 20% vs 43% +/- 12%, P < .05; and 25.02 +/- 9.43 ng/mL vs 8.6 +/- 3.7 ng/mL, P < .001, respectively). IL-8 in sputum supernatant was correlated to apnea hypopnea index (P < .01; r = 0.81). After 1 month of CPAP, this inflammatory pattern remained unchanged, and an increase in airway hyperresponsiveness (AHR) was observed (P < .001). CONCLUSION: Obstructive sleep apnea syndrome is associated with bronchial inflammation. Our data demonstrate CPAP effect on the development of AHR, possibly facilitated by the pre-existing inflammation. Both issues should be evaluated during long-term CPAP use. CLINICAL IMPLICATIONS: Results showing a spontaneous bronchial inflammation in OSA and the development of a CPAP-related AHR require a long-term follow-up to evaluate consequences on chronic bronchial obstruction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect