Disease Phenotypes and Gender Association of FCRL3 Single-Nucleotide Polymorphism −169T/C in Taiwanese Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis
| Autor: | Huei Huang Ho, Ji Yih Chen, Shin Ning Kuo, Yeong Jian Jan Wu, Chiung Fang Shiu, Chin Man Wang, Su-Wei Chang, Jianming Wu, Yen Tsun Lin |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Systemic disease Adolescent Genotype Immunology Single-nucleotide polymorphism Polymorphism Single Nucleotide Severity of Illness Index Arthritis Rheumatoid Gene Frequency Rheumatology Surveys and Questionnaires Immunopathology Internal medicine medicine Humans Lupus Erythematosus Systemic Immunology and Allergy Genetic Predisposition to Disease Receptors Immunologic Child Allele frequency Alleles Genetic Association Studies Aged Autoantibodies Aged 80 and over business.industry Autoantibody Middle Aged medicine.disease Connective tissue disease Logistic Models Phenotype Rheumatoid arthritis Female business |
| Zdroj: | The Journal of Rheumatology. 38:264-270 |
| ISSN: | 1499-2752 0315-162X |
| DOI: | 10.3899/jrheum.100437 |
| Popis: | Objective.To investigate the association of the functional FCRL3 single-nucleotide polymorphism (SNP) −169T/C with disease phenotypes and susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in Taiwanese.Methods.FCRL3 SNP −169T/C was genotyped in 573 patients with SLE, 670 patients with RA, and 758 controls. Genotype distributions and allele frequencies were compared among the 3 groups as aggregates or as stratified by clinical characteristics, autoantibody profile, and sex within patient groups.Results.Overall, FCRL3 SNP −169T/C was not associated with susceptibility to either SLE or RA. However, −169CC genotype was significantly reduced in leukopenia-positive SLE patients as compared to the leukopenia-negative SLE patients (CC vs CT+TT, p = 6 × 10−4, OR 0.444, 95% CI 0.279–0.708) and controls (p = 6.1 × 10−3, OR 0.583, 95% CI 0.396–0.857). On the other hand, −169TT genotypes were significantly more numerous in RA patients with non-destructive disease as compared with patients with destructive disease (CC+CT vs TT: p = 0.007, OR 1.672, 95% CI 1.149–2.432). The −169T allele frequency was also significantly increased in non-destructive RA compared with patients with destructive disease (C vs T: p = 0.010, OR 1.423, 95% CI 1.089–1.859). FCRL3 SNP −169TT homozygous donors were significantly more numerous among female cyclic citrullinated peptide (CCP)-negative RA patients versus female CCP-positive RA patients (CC+CT vs TT: p = 0.019, OR 1.64, 95% CI 1.085–2.479).Conclusion.The functional FCRL3 SNP −169T/C appears to play important roles in the development of certain phenotypes such as SLE leukopenia and RA disease severity in Taiwanese patients with SLE and RA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|