Observations on Dithiols and the Distribution of Lead in Rabbits
| Autor: | M. Weatherall, K. R. Adam |
|---|---|
| Rok vydání: | 1954 |
| Předmět: |
Pharmacology
medicine.medical_specialty Chemistry Dimercaprol Pharmaceutical Science Urine Excretion chemistry.chemical_compound Endocrinology Urinary excretion Lead Glucoside Internal medicine medicine Animals Distribution (pharmacology) Rabbits Sulfhydryl Compounds Lead (electronics) Toluene medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 6:403-409 |
| ISSN: | 2042-7158 0022-3573 |
| Popis: | Summary The influence of several dithiols on the acute distribution and excretion of lead salts has been studied in rabbits. Dimercaprol glucoside and 1:2-dimercaptopropionic acid were substantially more effective than dimercaprol in promoting the excretion of lead in the urine. 1:3-dimercaptopropanol and 1:4-dimercaptoerythritol were not more effective than dimercaprol. After dimercaprol glucoside the lead remaining in the body was distributed more uniformly than in the control animals. 5 After a tenfold increase in the dose of lead inequalities in the distribution were exaggerated. Dimercaprol and dimercaprol glucoside caused a bigger absolute increase in the urinary excretion of lead after this dose than after the smaller dose of lead. Relatively to the dose of lead, they were less effective. 6 The mechanism underlying these changes is discussed and a simple theory is put forward to account for them. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text