C-peptide: A predictor of cardiovascular mortality in subjects with established atherosclerotic disease
| Autor: | Chiara Pecchioli, Massimo Federici, Iris Cardolini, Francesca Davato, Arnaldo Ippoliti, Alessio Farcomeni, Valeria Guglielmi, Marina Cardellini, Stefano Rizza, Monica Morelli, Giulia Grappasonni, Ottavia Porzio, Marta Ballanti, Rossella Menghini |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism atherosclerosis biomarkers c-peptide cardiovascular diseases internal medicine endocrinology diabetes and metabolism cardiology and cardiovascular medicine 030209 endocrinology & metabolism Settore MED/11 - Malattie dell'Apparato Cardiovascolare Type 2 diabetes Settore MED/22 - Chirurgia Vascolare 03 medical and health sciences chemistry.chemical_compound endocrinology 0302 clinical medicine Insulin resistance Predictive Value of Tests Risk Factors Diabetes mellitus Internal medicine Cause of Death medicine Diabetes Mellitus Humans Hypoglycemic Agents Registries C-peptide Cardiovascular diseases diabetes and metabolism Cardiovascular mortality Aged Proportional Hazards Models C-Peptide business.industry Atherosclerotic disease Middle Aged medicine.disease Atherosclerosis 030104 developmental biology Endocrinology chemistry Chronic Disease Multivariate Analysis Linear Models Female business Biomarkers |
| Zdroj: | Diabetesvascular disease research. 14(5) |
| ISSN: | 1752-8984 |
| Popis: | Insulin resistance and type 2 diabetes are independent risk factors for cardiovascular diseases. Levels of C-peptide are increased in these patients and its role in the atherosclerosis progression was studied in vitro and in vivo over the past years. To evaluate the possible use of C-peptide as cardiovascular biomarkers, we designed an observational study in which we enrolled patients with mono- or poly-vascular atherosclerotic disease.We recruited 431 patients with stable atherosclerosis and performed a yearly follow-up to estimate the cardiovascular and total mortality and cardiovascular events.We performed a mean follow-up of 56 months on 268 patients. A multivariate Cox analysis showed that C-peptide significantly increased the risk of cardiovascular mortality [Hazard Ratio: 1.29 (95% confidence interval: 1.02-1.65, p0.03513)] after adjustment for age, sex, diabetes treatment, estimated glomerular filtration rate and known diabetes status. Furthermore, levels of C-peptide were significantly correlated with metabolic parameters and atherogenic factors.C-peptide was associated with cardiovascular mortality independently of known diabetes status in a cohort of patients with chronic atherosclerotic disease. Future studies using C-peptide into a reclassification approach might be undertaken to consider its potential as a cardiovascular disease biomarker. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|