Modeling the onset and offset of dental pain relief by ibuprofen
| Autor: | Jaap W. Mandema, Paul J. Desjardins, David Kellstein, Russell Wada, Shyamalie Jayawardena, Geraldine Doyle, Hanbin Li |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Analgesics.non-narcotic Adolescent Pain relief Ibuprofen Placebo Models Biological Young Adult Pharmacokinetics Double-Blind Method Toothache medicine Hazard model Humans Pharmacology (medical) Pain Measurement Pharmacology Pain Postoperative business.industry organic chemicals Anti-Inflammatory Agents Non-Steroidal Analgesics Non-Narcotic Anesthesia Plasma concentration Female medicine.symptom business medicine.drug |
| Zdroj: | Journal of clinical pharmacology. 52(1) |
| ISSN: | 1552-4604 |
| Popis: | Onset and offset of dental pain relief by ibuprofen following third molar extraction were modeled in a randomized, double-blind, placebo-controlled, parallel-group, 8-hour study of patients receiving either a novel effervescent ibuprofen tablet (400 mg; N = 30), standard ibuprofen tablets (Nurofen(®) 2 × 200 mg; N = 22), or placebo (N = 37). An Emax model was fit to pain relief scores. Linear hazard models were used to analyze the time to first perceptible relief (TFPR), the time to meaningful pain relief (TMPR), and time to remedication (REMD). Nomograms were created to correlate TFPR, TMPR, and REMD with different ibuprofen pharmacokinetic profiles. Effervescent ibuprofen was absorbed rapidly with 95% completion within 15 minutes. Maximum pain relief score by ibuprofen was 1.8 units greater than placebo, with an EC50 (effect-site) for ibuprofen concentration of 10.2 µg·mL(-1). The likelihood to achieve TFPR and TMPR was doubled for every 10 µg·mL(-1) increase in ibuprofen plasma concentration. REMD risk decreased 40-fold as the categorical pain relief score increased from 0 to 3. Rapid absorption of ibuprofen effervescent resulted in an earlier TFPR and TMPR, and a lower REMD rate than standard ibuprofen. The nomograms may be useful in predicting the onset and offset of new faster acting ibuprofen formulations, based on pharmacokinetic profiles. |
| Databáze: | OpenAIRE |
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