Additive Antihypertensive and Antihypertrophic Effects of Long-Acting Ca Blockers in Uncontrolled Hypertensive Patients With Angiotensin-Receptor Blocker Based Treatment
| Autor: | Yukiko Inoue, Hidenori Urata, Hideaki Tojyo, Chie Ando, Yoshio Yamanouchi, Sunao Kodama, Shunichiro Sumi, Kei Miyoshi, Hideya Niimura, Yoshihiro Tsuchiya, Keisuke Okamura, Hiroyuki Mihara |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Angiotensin receptor Nifedipine Tetrazoles Pharmacology Essential hypertension Losartan medicine Humans Amlodipine Aged business.industry Biphenyl Compounds Antagonist General Medicine Middle Aged Calcium Channel Blockers medicine.disease Candesartan Blood pressure Hypertension Benzimidazoles Drug Therapy Combination Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | International Heart Journal. 50:555-570 |
| ISSN: | 1349-3299 1349-2365 |
| DOI: | 10.1536/ihj.50.555 |
| Popis: | The aim of the present study was to examine the antihypertensive and antihypertrophic effects of combined treatment with a long-acting calcium antagonist on top of an angiotensin II receptor blocker (ARB) in uncontrolled hypertensive patients. Patients with essential hypertension and a blood pressure > 140/90 mmHg on ARB monotherapy (losartan 50 mg/day or candesartan 8 mg/day) were randomly assigned to a nifedipine controlled release (CR) group (n = 15) or amlodipine group (n = 11). A significant additional antihypertensive effect was noted from 1 month with nifedipine and 2 months with amlodipine. The average daily dose was 25 mg for nifedipine and 5 mg for amlodipine. The cardiothoracic ratio was significantly reduced in both groups after 3 months. Left ventricular wall thickness and left ventricular mass index also decreased. Metabolic parameters, hepatic function, and renal function did not change significantly. Additional treatment with a long-acting calcium antagonist achieved further blood pressure reduction as well as an antihypertrophic effect in the uncontrolled patients with prior ARB monotherapy. |
| Databáze: | OpenAIRE |
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