Deoxypodophyllotoxin Exerts Anti-Cancer Effects on Colorectal Cancer Cells Through Induction of Apoptosis and Suppression of Tumorigenesis
| Autor: | Jung-Hyun Shim, Kyung Keun Kim, Chathurika D.B. Gamage, İsa Taş, So-Yeon Park, Woo Kyun Bae, Eunae Kim, Goo Yoon, Rui Zhou, Hangun Kim, Yi Yang |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Carcinogenesis Colorectal cancer Motility Antineoplastic Agents colorectal cancer medicine.disease_cause Microtubules complex mixtures Article Catalysis lcsh:Chemistry Inorganic Chemistry Mice In vivo medicine otorhinolaryngologic diseases Animals Humans Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy deoxypodophyllotoxin Podophyllotoxin Mice Inbred BALB C Cell growth Chemistry tumorigenic potentials Organic Chemistry apoptosis Cancer General Medicine mitotic arrest medicine.disease Tubulin Modulators Computer Science Applications tubulin polymerization lcsh:Biology (General) lcsh:QD1-999 Cell culture Apoptosis Cancer research Caco-2 Cells Colorectal Neoplasms HT29 Cells Drugs Chinese Herbal |
| Zdroj: | International Journal of Molecular Sciences Volume 20 Issue 11 International Journal of Molecular Sciences, Vol 20, Iss 11, p 2612 (2019) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms20112612 |
| Popis: | Deoxypodophyllotoxin (DPT) is a cyclolignan compound that exerts anti-cancer effects against various types of cancers. DPT induces apoptosis and inhibits the growth of breast, brain, prostate, gastric, lung, and cervical tumors. In this study, we sought to determine the effect of DPT on cell proliferation, apoptosis, motility, and tumorigenesis of three colorectal cancer (CRC) cell lines: HT29, DLD1, and Caco2. DPT inhibited the proliferation of these cells. Specifically, the compound-induced mitotic arrest in CRC cells by destabilizing microtubules and activating the mitochondrial apoptotic pathway via regulation of B-cell lymphoma 2 (Bcl-2) family proteins (increasing Bcl-2 associated X (BAX) and decreasing B-cell lymphoma-extra-large (Bcl-xL)) ultimately led to caspase-mediated apoptosis. In addition, DPT inhibited tumorigenesis in vitro, and in vivo skin xenograft experiments revealed that DPT significantly decreased tumor size and tumor weight. Taken together, our results suggest DPT to be a potent compound that is suitable for further exploration as a novel chemotherapeutic for human CRC. |
| Databáze: | OpenAIRE |
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