Revisão sistemática da aplicação de derivados perinatais em modelos animais em cicatriz cutânea
| Autor: | Melanie Pichlsberger, Urška Dragin Jerman, Hristina Obradović, Larisa Tratnjek, Ana Sofia Macedo, Francisca Mendes, Pedro Fonte, Anja Hoegler, Monika Sundl, Julia Fuchs, Andreina Schoeberlein, Mateja Erdani Kreft, Slavko Mojsilović, Ingrid Lang-Olip |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
skin
Histology placenta medicine.medical_treatment Placenta Cells Intraperitoneal injection Biomedical Engineering Preclinical studies Wound healing wound healing Bioengineering 610 Medicine & health Bioinformatics Umbilical cord 03 medical and health sciences Route of administration Subcutaneous injection Perinatal derivatives 0302 clinical medicine perinatal derivatives In vivo Medicine preclinical studies 030304 developmental biology Skin 0303 health sciences Fetus business.industry cutaneous Bioengineering and Biotechnology animal models 3. Good health Animal models medicine.anatomical_structure Cutaneous 030220 oncology & carcinogenesis cells Systematic Review business TP248.13-248.65 Biotechnology |
| Zdroj: | Pichlsberger, Melanie; Jerman, Urška Dragin; Obradović, Hristina; Tratnjek, Larisa; Macedo, Ana Sofia; Mendes, Francisca; Fonte, Pedro; Hoegler, Anja; Sundl, Monika; Fuchs, Julia; Schoeberlein, Andreina; Kreft, Mateja Erdani; Mojsilović, Slavko; Lang-Olip, Ingrid (2021). Systematic Review of the Application of Perinatal Derivatives in Animal Models on Cutaneous Wound Healing. Frontiers in Bioengineering and Biotechnology, 9, p. 742858. Frontiers Media 10.3389/fbioe.2021.742858 Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Frontiers in Bioengineering and Biotechnology Frontiers in Bioengineering and Biotechnology, Vol 9 (2021) |
| DOI: | 10.48350/163899 |
| Popis: | Knowledge of the beneficial effects of perinatal derivatives (PnD) in wound healing goes back to the early 1900s when the human fetal amniotic membrane served as a biological dressing to treat burns and skin ulcerations. Since the twenty-first century, isolated cells from perinatal tissues and their secretomes have gained increasing scientific interest, as they can be obtained non-invasively, have anti-inflammatory, anti-cancer, and anti-fibrotic characteristics, and are immunologically tolerated in vivo. Many studies that apply PnD in pre-clinical cutaneous wound healing models show large variations in the choice of the animal species (e.g., large animals, rodents), the choice of diabetic or non-diabetic animals, the type of injury (full-thickness wounds, burns, radiation-induced wounds, skin flaps), the source and type of PnD (placenta, umbilical cord, fetal membranes, cells, secretomes, tissue extracts), the method of administration (topical application, intradermal/subcutaneous injection, intravenous or intraperitoneal injection, subcutaneous implantation), and the type of delivery systems (e.g., hydrogels, synthetic or natural biomaterials as carriers for transplanted cells, extracts or secretomes). This review provides a comprehensive and integrative overview of the application of PnD in wound healing to assess its efficacy in preclinical animal models. We highlight the advantages and limitations of the most commonly used animal models and evaluate the impact of the type of PnD, the route of administration, and the dose of cells/secretome application in correlation with the wound healing outcome. This review is a collaborative effort from the COST SPRINT Action (CA17116), which broadly aims at approaching consensus for different aspects of PnD research, such as providing inputs for future standards for the preclinical application of PnD in wound healing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|