Prism adaptation in spinocerebellar ataxia type 2
| Autor: | Ruth Pérez-González, Juan Fernandez-Ruiz, René Drucker-Colín, Yaquelín Medrano, E Martínez-Góngora, Georg Auburger, Luis E. Almaguer-Mederos, Rosalinda Diaz, Luis Velásquez-Perez, Carola Seifried, Nalia Canales, Sánchez-Cruz G |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities Cerebellum Adolescent Cognitive Neuroscience Purkinje cell Experimental and Cognitive Psychology Neuropsychological Tests Behavioral Neuroscience Dysarthria Autosomal dominant cerebellar ataxia Figural Aftereffect medicine Saccades Humans Learning Spinocerebellar Ataxias Aged Pontine nuclei Electronystagmography Middle Aged medicine.disease Adaptation Physiological medicine.anatomical_structure Spinocerebellar ataxia Female medicine.symptom Motor learning Psychology Prism adaptation Neuroscience Psychomotor Performance |
| Zdroj: | Neuropsychologia. 45(12) |
| ISSN: | 0028-3932 |
| Popis: | Patients with spinocerebellar ataxia type 2 (SCA2), develop severe pontine nuclei, inferior olives, and Purkinje cell degeneration. This form of autosomal dominant cerebellar ataxia is accompanied by progressive ataxia and dysarthria. Although the motor dysfunction is well characterized in these patients, nothing is known about their motor learning capabilities. Here we tested 43 SCA2 patients and their matched controls in prism adaptation, a kind of visuomotor learning task. Our results show that their pattern of brain damage does not entirely disrupt motor learning. Rather, patients had impaired adaptation decrement, but surprisingly a normal aftereffect. Moreover, the mutation degree could discriminate the degree of adaptation. This pattern could reflect the net contribution of two adaptive mechanisms: strategic control and spatial realignment. Accordingly, SCA2 patients show an impaired strategic control that affects the adaptation rate, but a normal spatial realignment measured through the aftereffect. Our results suggest that the neural areas subserving spatial realignment are spared in this form of spinocerebellar ataxia. |
| Databáze: | OpenAIRE |
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