Plasma levels in sepsis patients of annexin A1, lipoxin A4, macrophage inflammatory protein-3a, and neutrophil gelatinase-associated lipocalin
| Autor: | Hui Chi Hsu, Wen Hui Tsai, Chung Hung Shih, Yuan Bin Yu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_treatment Lipocalin Proinflammatory cytokine Sepsis sepsis chemistry.chemical_compound Lipocalin-2 Proto-Oncogene Proteins Medicine Humans Macrophage inflammatory protein Aged Medicine(all) Aged 80 and over Lipoxin lcsh:R5-920 Chemokine CCL20 business.industry lipoxin A4 Interleukin neutrophil gelatinase-associated lipocalin General Medicine Middle Aged medicine.disease annexin A1 Lipocalins Lipoxins Cytokine chemistry macrophage inflammatory protein-3a Immunology Female business lcsh:Medicine (General) Annexin A1 Acute-Phase Proteins |
| Zdroj: | Journal of the Chinese Medical Association, Vol 76, Iss 9, Pp 486-490 (2013) |
| ISSN: | 1726-4901 |
| Popis: | Background: The relationship between the various cytokine responses that occur during sepsis remains controversial. Emerging evidence indicates that the proinflammatory and anti-inflammatory responses are regulated simultaneously from the beginning of sepsis. However, the roles of the novel anti-inflammatory mediators annexin (Anx)A1 and lipoxin (LX)A4 and the proinflammatory cytokines neutrophil gelatinase-associated lipocalin (NGAL) and macrophage inflammatory protein (MIP)-3a have been studied. Methods: In this study, the plasma levels of AnxA1, LXA4, NGAL, MIP-3a, interleukin (IL)-8 and IL-6 in patients with sepsis were determined on admission to the intensive care unit. The patients were classified into survivors and non-survivors based on their outcome on day 28. Results: AnxA1 and LXA4 levels were decreased in sepsis patients compared with control patients, whereas the levels of the proinflammatory cytokines MIP-3a, NGAL, IL-8, and IL-6 were elevated. Furthermore, a significantly higher level of MIP-3a was detected in nonsurviving patients compared with surviving patients (p |
| Databáze: | OpenAIRE |
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