TBLR1 and CREBBP as potential novel prognostic immunohistochemical biomarkers in diffuse large B-cell lymphoma
| Autor: | Mimmie Stern, Henrik Fagman, Susanne Bram Ednersson, Sverker Hasselblom, Per-Ola Andersson, Herman Nilsson-Ehle |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Negatively associated Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Nuclear protein Cyclophosphamide business.industry EZH2 Hematology medicine.disease Prognosis CREB-Binding Protein Lymphoma Doxorubicin Vincristine 030220 oncology & carcinogenesis Digital image analysis Immunohistochemistry Prednisone Lymphoma Large B-Cell Diffuse IRF8 business Rituximab Diffuse large B-cell lymphoma Biomarkers 030215 immunology |
| Zdroj: | Leukemialymphoma. 61(11) |
| ISSN: | 1029-2403 |
| Popis: | Recent studies have identified prognostic mutational clusters for diffuse large B-cell lymphoma (DLBCL) patients, both within and outside the original cell-of-origin (COO) classification. For many of these mutations, there is limited information regarding the corresponding protein expression. With the aim to determine the relationship of protein expression and intensity to COO and prognosis, we used digital image analysis to quantitate immunohistochemical staining of CREBBP, IRF8, EZH2, and TBLR1 in 209 DLBCL patients. We found that patients with strong nuclear expression of TBLR1 had inferior progression-free survival (PFS) and overall survival (OS) in univariable analysis and inferior PFS in multivariable analysis. Patients with higher proportion of intermediate to strong nuclear CREBBP expression had a worse PFS and OS in univariable analysis. CREBBP was expressed with stronger intensity in non-GCB patients and the prognostic impact was restricted to this subgroup. These findings suggest that high nuclear protein expression of TBLR1 and CREBBP is negatively associated with prognosis in DLBCL. |
| Databáze: | OpenAIRE |
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