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Purpose: to study the main pathomorphological and morphometric structural rearrangements of tissue formations of the thyroid gland (TG) in diffuse toxic goiter (DTG). Material and methods: the macro- and microscopic structural features of the thyroid gland were studied using the methods of anatomical dissection and histological sections in 15 patients with DTG, both sexes aged from 36 to 60 years old, operated on in the department of general surgery in Chernivtsi. Results: the analysis of the degree of progression of pathomorphological changes in the tissue and follicular structure of the thyroid revealed a dependence on the duration and severity of the disease. The results of the quantitative study showed that the average diameter of the follicles compared to the norm (71.8±0.98 μm) became larger (82.3±1.12 μm). The height of the follicular epithelium in this pathology was equal to 16.10±0.12 μm, in the normal case it was 11.06±0.1 μm (р |