Applications of Raman spectroscopy in skin research — From skin physiology and diagnosis up to risk assessment and dermal drug delivery
| Autor: | Maike Windbergs, Lutz Franzen |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Materials science
Skin Absorption Confocal Skin physiology Pharmaceutical Science Nanotechnology Administration Cutaneous Spectrum Analysis Raman Risk Assessment Skin Diseases law.invention symbols.namesake Drug Delivery Systems Confocal microscopy law Skin Physiological Phenomena Microscopy High spatial resolution Animals Humans Skin integumentary system Analytical technique Drug delivery symbols Raman spectroscopy |
| Zdroj: | Advanced Drug Delivery Reviews. 89:91-104 |
| ISSN: | 0169-409X |
| DOI: | 10.1016/j.addr.2015.04.002 |
| Popis: | In the field of skin research, confocal Raman microscopy is an upcoming analytical technique. Substantial technical progress in design and performance of the individual setup components like detectors and lasers as well as the combination with confocal microscopy enables chemically selective and non-destructive sample analysis with high spatial resolution in three dimensions. Due to these advantages, the technique bears tremendous potential for diverse skin applications ranging from the analysis of physiological component distribution in skin tissue and the diagnosis of pathological states up to biopharmaceutical investigations such as drug penetration kinetics within the different tissue layers. This review provides a comprehensive introduction about the basic principles of Raman microscopy highlighting the advantages and considering the limitations of the technique for skin applications. Subsequently, an overview about skin research studies applying Raman spectroscopy is given comprising various in vitro as well as in vivo implementations. Furthermore, the future perspective and potential of Raman microscopy in the field of skin research are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect