Troponin elevation in COVID-19 patients: An important stratification biomarker with still some open questions

Autor: Alessandro Maloberti, Cristina Giannattasio, Marco Biolcati
Přispěvatelé: Maloberti, A, Biolcati, M, Giannattasio, C
Rok vydání: 2021
Předmět:
Rome
WBC
white blood cells
ACEi
angiotensin-converting enzyme inhibitor
Stratification (mathematics)
COVID-19 Testing
Prevalence
Hospital Mortality
CE
angiotensin-converting enzyme
COVID-19
coronavirus disease 2019
biology
Hs-Tn
high sensitive troponin
ICU
intensive care unit
Troponin
Elevation (emotion)
Editorial
Italy
Myocardial injury
CRP
C-reactive protein
Cardiology
Biomarker (medicine)
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
CMR
cardiovascular magnetic resonance
Heart failure
AKI
acute kidney injury
CVD
cardiovascular disease
Article
Internal medicine
medicine
Humans
Pandemics
ARDS
acute respiratory distress syndrome
Retrospective Studies
SARS-CoV-2
business.industry
Troponin I
CKD
chronic kidney disease
COVID-19
MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE
ARB
angiotensin II receptor blocker
MRA
antimineralocorticoid
MOF
multiorgan failure
covid
troponin
cardiovascular
Coronavirus
biology.protein
business
Biomarkers
SARS-CoV-2
severe acute respiratory syndrome coronavirus-2
Zdroj: International Journal of Cardiology
ISSN: 0167-5273
Popis: Background Coronavirus disease 2019 (COVID-19) is a pandemic disease that is causing a public health emergency. Characteristics and clinical significance of myocardial injury remain unclear. Methods This retrospective single-center study analyzed 189 patients who received a COVID-19 diagnosis out of all 758 subjects with a high sensitive troponin I (Hs-TnI) measurement within the first 24 h of admission at the Policlinico A.Gemelli (Rome, Italy) between February 20th 2020 to April 09th 2020. Results The prevalence of myocardial injury in our COVID-19 population is of 16%. The patients with cardiac injury were older, had a greater number of cardiovascular comorbidities and higher values of acute phase and inflammatory markers and leucocytes. They required more frequently hospitalization in Intensive Care Unit (10 [32.3%] vs 18 [11.4%]; p = .003) and the mortality rate was significantly higher (17 [54.8%] vs. 15 [9.5%], p < .001). Among patients in ICU, the subjects with myocardial injury showed an increase need of endotracheal intubation (8 out of 9 [88%] vs 7 out of 19[37%], p = .042). Multivariate analyses showed that hs-TnI can significantly predict the degree of COVID-19 disease, the intubation need and in-hospital mortality. Conclusions In this study we demonstrate that hs-Tn can significantly predict disease severity, intubation need and in-hospital death. Therefore, it may be reasonable to use Hs-Tn as a clinical tool in COVID-19 patients in order to triage them into different risk groups and can play a pivotal role in the detection of subjects at high risk of cardiac impairment during both the early and recovery stage.
Databáze: OpenAIRE
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