Potential Selection Effects when Estimating Associations Between the Infancy Peak or Adiposity Rebound and Later Body Mass Index in Children
Autor: | Dénes Molnár, A. De Decker, Iris Pigeot, L. A. Moreno, Wolfgang Ahrens, Lucia A. Reisch, Claudia Börnhorst, Michael Tornaritis, Susann Regber, Alfonso Siani, Lauren Lissner |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Male
Pediatric Obesity Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Overweight Weight Gain Body Mass Index Cohort Studies 0302 clinical medicine Child Development Risk Factors Odds Ratio 030212 general & internal medicine Prospective cohort study Child Adiposity Nutrition and Dietetics Europe Child Preschool Female medicine.symptom Child Nutritional Physiological Phenomena Cohort study medicine.medical_specialty Nutritional Status 030209 endocrinology & metabolism Childhood obesity 03 medical and health sciences Age Distribution children adiposity rebound Classification of obesity Internal medicine medicine Humans Life Style Epidemiology Obesity Paediatric research Body mass index Risk factors business.industry Infant Newborn Infant nutritional and metabolic diseases Odds ratio medicine.disease Diet Endocrinology IDEFICS business Energy Intake Weight gain Demography |
Zdroj: | International journal of obesity, 41:518-526 International journal of obesity 41 (2017): 518–526. doi:10.1038/ijo.2016.218 info:cnr-pdr/source/autori:Boernhorst, C.; Siani, A.; Tornaritis, M.; Molnar, D.; Lissner, L.; Regber, S.; Reisch, L.; De Decker, A.; Moreno, L. A.; Ahrens, W.; Pigeot, I./titolo:Potential selection effects when estimating associations between the infancy peak or adiposity rebound and later body mass index in children/doi:10.1038%2Fijo.2016.218/rivista:International journal of obesity/anno:2017/pagina_da:518/pagina_a:526/intervallo_pagine:518–526/volume:41 |
ISSN: | 1476-5497 0307-0565 |
Popis: | INTRODUCTION: This study aims to evaluate a potential selection effect caused by exclusion of children with non-identifiable infancy peak (IP) and adiposity rebound (AR) when estimating associations between age and body mass index (BMI) at IP and AR and later weight status. SUBJECTS AND METHODS: In 4744 children with at least 4 repeated measurements of height and weight in the age interval from 0 to 8 years (37 998 measurements) participating in the IDEFICS (Identification and Prevention of Dietary- and Lifestyle-Induced Health Effects in Children and Infants)/I.Family cohort study, fractional polynomial multilevel models were used to derive individual BMI trajectories. Based on these trajectories, age and BMI at IP and AR, BMI values and growth velocities at selected ages as well as the area under the BMI curve were estimated. The BMI growth measures were standardized and related to later BMI z-scores (mean age at outcome assessment: 9.2 years). RESULTS: Age and BMI at IP and AR were not identifiable in 5.4% and 7.8% of the children, respectively. These groups of children showed a significantly higher BMI growth during infancy and childhood. In the remaining sample, BMI at IP correlated almost perfectly (r?0.99) with BMI at ages 0.5, 1 and 1.5 years, whereas BMI at AR correlated perfectly with BMI at ages 4-6 years (r?0.98). In the total study group, BMI values in infancy and childhood were positively associated with later BMI z-scores where associations increased with age. Associations between BMI velocities and later BMI z-scores were largest at ages 5 and 6 years. Results differed for children with non-identifiable IP and AR, demonstrating a selection effect. CONCLUSIONS: IP and AR may not be estimable in children with higher-than-average BMI growth. Excluding these children from analyses may result in a selection bias that distorts effect estimates. BMI values at ages 1 and 5 years might be more appropriate to use as predictors for later weight status instead. |
Databáze: | OpenAIRE |
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