Is Resolution the End of Inflammation?
Autor: | Karen Feehan, Derek W. Gilroy |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Inflammation medicine.disease_cause Autoimmunity 03 medical and health sciences 0302 clinical medicine Immune system Medicine Animals Humans Molecular Biology business.industry Immunity 030104 developmental biology Acute Disease Chronic Disease Molecular Medicine Cytokines Disease Susceptibility medicine.symptom Inflammation Mediators business Neuroscience 030217 neurology & neurosurgery Homeostasis Function (biology) Biomarkers Signal Transduction |
Zdroj: | Trends in molecular medicine. 25(3) |
ISSN: | 1471-499X |
Popis: | Deciphering the origins of chronic inflammatory and autoimmune diseases remains elusive with reliance on therapies aimed at halting inflammation in its tracks. In recent years, an appreciation of targeting pathways by which inflammation is resolved has begun to rouse interest. Resolution of inflammation is driven by a complex set of mediators that regulate cellular events required to clear inflammatory cells from sites of infection or injury to restore tissue function. However, recent studies suggest that resolution is not the end of innate mediated immune responses to infection/injury. There is further immunological activity occurring after the resolution cascade is complete that alters the immune physiology of tissues, redefining what was once termed restorative homeostasis as adapted homeostasis. |
Databáze: | OpenAIRE |
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