Role of oncogene 24p3 neutrophil gelatinase-associated lipocalin (NGAL) in digestive system cancers
| Autor: | Katarzyna Kudłacz, Piotr Szcześniak, Magdalena Bulska, Łukasz Michalak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Microbiology (medical)
Retinol transport lcsh:Medicine Inflammation Lipocalin 010402 general chemistry Digestive System Neoplasms 01 natural sciences Lcn2 Lipocalin-2 Pancreatic cancer Medicine Gelatinase Humans NGAL education education.field_of_study lipokalina 2 biology business.industry Lactoferrin lcsh:R medicine.disease 0104 chemical sciences lipokalina neutrofilowa związana z żelatynazą Infectious Diseases Oncogene 24p3 nowotwory biology.protein Cancer research Calprotectin medicine.symptom business uterokalina |
| Zdroj: | Postępy Higieny i Medycyny Doświadczalnej, Vol 70, Pp 1026-1031 (2016) |
| ISSN: | 1732-2693 0032-5449 |
| Popis: | Neutrophil gelatinase-associated lipocalin, known also as 24p3 lipocalin, lipocalin-2 or uterocalin (in mouse), is a small secretory protein binding small molecular weight ligands which takes part in numerous processes including apoptosis induction in leukocytes, iron transport, smell, and prostaglandins and retinol transport [19]. It was discovered in activated neutrophils as a covalent peptide associated with human gelatinase neutrophils [7]. Neutrophil lipocalin is secreted physiologically in the digestive system, respiratory tract, renal tubular cells, liver or immunity system. Systematic (circulated in plasma) neutrophil gelatinase come from multiple sources; it may be synthesized in the liver, secreted from activated neutrophils or macrophages, or derive from atherosclerosis or inflammatory endothelial cells [17]. NGAL is stored secondarily in granulates with lactoferrin, calprotectin or MAC-1, which take part in neutrophils' action and migration [13,19]. NGAL participates in acute and chronic inflammation (production of NGAL is indicated by factors conducive to cancer progression) [13,21]. NGAL levels increase in inflammatory or endothelial damage. NGAL level is measured in blood or urine. It is known as a kidney failure factor [7,20]. NGAL is therefore one of the most promising new generation biomarkers in clinical nephrology [6]. The role of NGAL in digestive system neoplasms has not been explored in detail. However, overexpression of this marker was proved in neoplasms such as esophageal carcinoma, stomach cancer, pancreatic cancer or colon cancer, which may indicate an association between concentration and neoplasm [3]. |
| Databáze: | OpenAIRE |
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