Evaluation of osteogenic potential of Cissus quadrangularis on mandibular alveolar ridge distraction
| Autor: | Marwa A M Elshiekh, Hazem Shawky Shoshan, Abd El-Hamid Gaber, Hisham Mohamed Abbas, Amr Abdelfatah Zewail, Ahmed Abdel-Shakour Abdel-Hafiz, Alaa Abdelqader Altaweel, Abdel Aziz Baiomy Abdullah Baiomy |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Bone density
Osteogenesis Distraction Dentistry Mandible law.invention Randomized controlled trial law Osteogenesis Alveolar ridge Medicine Cissus quadrangularis Quadrangularis Humans Cissus Tooth Socket Osteogenic General Dentistry biology business.industry Research Dental Implantation Endosseous Distraction Increased Bone Density RK1-715 Alveolar Ridge Augmentation biology.organism_classification Oral and maxillofacial surgery Implant business |
| Zdroj: | BMC Oral Health BMC Oral Health, Vol 21, Iss 1, Pp 1-8 (2021) |
| ISSN: | 1472-6831 |
| Popis: | Background This randomized clinical trial was designed to evaluate osteogenic potential of Cissus quadrangularis in alveolar distraction to facilitate implant installation. Material and methods Twenty patients with atrophic ridge were treated by alveolar distraction. After completing distractor activation, patients were randomly divided into two equal groups according to administered drug (placebo and Cissus quadrangularis group). After a consolidation period, distractors were removed and implants were inserted. Clinical evaluation was done to assess wound healing, and distractor and implant stability. Histological evaluation was performed at time of implant insertion. Radiographic evaluation was performed to assess bone volume and density after distraction, as well as, density and bone loss around implant. Results Radiographic and histological results showed that bone formation and maturation of study group were faster than that of control group. There was a significant increased bone density in distracted area and around implant in study group than control group. A significant bone loss at end of consolidation period, and around implant at end of the study was reported in control group than study group. Conclusion Cissus quadrangularis administration during the consolidation period is associated with increased osteogenic potential of distracted bone. The histological and radiographic findings of current study proved that Cissus quadrangularis not only enhances rate of new bone formation, but also bone density to withstand the biomechanical requirements of implant placement in a shorter time. Trial registration This study was retrospectively registered on www.ClinicalTrial.gov: NCT04669795-17\12\2020. |
| Databáze: | OpenAIRE |
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