Signaling through the Prostaglandin I 2 Receptor IP Protects against Respiratory Syncytial Virus-Induced Illness

Autor: Weisong Zhou, Koichi Hashimoto, Peter F. Wright, R. Stokes Peebles, Jamye F. O'Neal, Robert D. Collins, Jason D. Morrow, Karine Egan, Kasia Goleniewska, Tatsuo Suzutani, Mark W. Geraci, Barney S. Graham, Russell K. Durbin, Garret A. FitzGerald
Rok vydání: 2004
Předmět:
Male
Paramyxoviridae
viruses
Immunology
Alpha interferon
Prostaglandin
Mice
Transgenic
Pulmonary Edema
6-Ketoprostaglandin F1 alpha
Respiratory Mucosa
Respiratory Syncytial Virus Infections
Antibodies
Viral
Receptors
Epoprostenol
Microbiology
Virus
Interferon-gamma
Mice
chemistry.chemical_compound
Cytochrome P-450 Enzyme System
Virology
Weight Loss
medicine
Animals
Interferon gamma
Mononegavirales
Lung
Pulmonary Surfactant-Associated Protein B
Pulmonary Surfactant-Associated Protein A
biology
Interferon-alpha
Interferon-beta
respiratory system
biology.organism_classification
Epoprostenol
Respiratory Syncytial Viruses
Intramolecular Oxidoreductases
Disease Models
Animal
medicine.anatomical_structure
Viral replication
chemistry
Insect Science
Pathogenesis and Immunity
Female
lipids (amino acids
peptides
and proteins)
Gene Deletion
Signal Transduction
Respiratory tract
medicine.drug
Zdroj: Journal of Virology. 78:10303-10309
ISSN: 1098-5514
0022-538X
DOI: 10.1128/jvi.78.19.10303-10309.2004
Popis: The role of prostanoids in modulating respiratory syncytial virus (RSV) infection is unknown. We found that RSV infection in mice increases production of prostaglandin I 2 (PGI 2 ). Mice that overexpress PGI 2 synthase selectively in bronchial epithelium are protected against RSV-induced weight loss and have decreased peak viral replication and gamma interferon levels in the lung compared to nontransgenic littermates. In contrast, mice deficient in the PGI 2 receptor IP have exacerbated RSV-induced weight loss with delayed viral clearance and increased levels of gamma interferon in the lung compared to wild-type mice. These results suggest that signaling through IP has antiviral effects while protecting against RSV-induced illness and that PGI 2 is a potential therapeutic target in the treatment of RSV.
Databáze: OpenAIRE
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