High-performance liquid chromatographic enantioseparation of methanobenzazocines
| Autor: | Karin Worm, Roland E. Dolle, William M. Barker |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
Chromatography Resolution (mass spectrometry) Cyclodextrin Chemistry Organic Chemistry Enantioselective synthesis Stereoisomerism General Medicine Biochemistry Chiral resolution Analytical Chemistry Inclusion compound Chiral column chromatography chemistry.chemical_compound Benzomorphans Organic chemistry Enantiomer Chiral derivatizing agent Chromatography High Pressure Liquid |
| Zdroj: | Journal of chromatography. A. 1216(45) |
| ISSN: | 1873-3778 |
| Popis: | Chiral recognition and resolution of methanobenzazocines was investigated by HPLC using polysaccharide, Pirkle-type, native and derivatized beta-cyclodextrin chiral stationary phases. Enantioseparation of phenyl substituted 2,6-methanobenzazocines was achieved with multiple chiral stationary phases throughout the classes described. Chiral resolution of the enantiomers of 1,5-methano-3-methyl-6-oxo-1,2,3,4,5,6-hexahydro-3-benzazocine was produced on both polysaccharide and Pirkle-type phases. In the case of 1,5-methano-3-methyl-6-phenyl-1,2,3,4,5,6-hexahydro-3-benzazocine only a dinitrophenyl substituted beta-cyclodextrin produced a separation of enantiomers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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