Exercise Prevents Fructose-Induced Hypertriglyceridemia in Healthy Young Subjects
| Autor: | Philippe Schneiter, Virgile Lecoultre, Vanessa Campos, Bettina Mittendorfer, Bruce W. Patterson, Fanny Theytaz, Leanne Hodson, Barbara A. Fielding, Luc Tappy, Philipp A. Gerber, Vittorio Giusti, Kaspar Berneis, Léonie Egli |
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| Přispěvatelé: | University of Zurich, Tappy, Luc |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Apolipoprotein B Adolescent Endocrinology Diabetes and Metabolism 10265 Clinic for Endocrinology and Diabetology 610 Medicine & health Fructose chemistry.chemical_compound Young Adult Insulin resistance Internal medicine Internal Medicine medicine Aerobic exercise Humans Exercise physiology Exercise Original Research Hypertriglyceridemia Cross-Over Studies biology medicine.disease Lipid Metabolism Diet 2712 Endocrinology Diabetes and Metabolism Endocrinology Metabolism chemistry 2724 Internal Medicine biology.protein Energy Metabolism Dyslipidemia Lipoprotein |
| Zdroj: | Diabetes Diabetes, vol. 62, no. 7, pp. 2259-2265 |
| ISSN: | 1939-327X 0012-1797 |
| Popis: | Excess fructose intake causes hypertriglyceridemia and hepatic insulin resistance in sedentary humans. Since exercise improves insulin sensitivity in insulin-resistant patients, we hypothesized that it would also prevent fructose-induced hypertriglyceridemia. This study was therefore designed to evaluate the effects of exercise on circulating lipids in healthy subjects fed a weightmaintenance, high-fructose diet. Eight healthy males were studiedj on three occasions after 4 days of 1) a diet low in fructose and no exercise (C), 2) a diet with 30% fructose and no exercise (HFr), or 3) a diet with 30% fructose and moderate aerobic exercise (HFrEx). On all three occasions, a 9-h oral [13C]-labeled fructose loading test was performed on the fifth day to measure [13C]palmitate in triglyceride-rich lipoprotein (TRL)-triglycerides (TG). Compared with C, HFr significantly increased fasting glucose, total TG, TRL-TG concentrations, and apolipoprotein (apo) B48 concentrations as well as postfructose glucose, total TG, TRLTG, and [13C]palmitate in TRL-TG. HFrEx completely normalized fasting and postfructose TG, TRL-TG, and [13C]palmitate concentration in TRL-TG and apoB48 concentrations. In addition, it increased lipid oxidation and plasma nonesterified fatty acid concentrations compared with HFr. These data indicate that exercise prevents the dyslipidemia induced by high fructose intake independently of energy balance. © 2013 by the American Diabetes Association. |
| Databáze: | OpenAIRE |
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