In vitrotransformation of dithiopyr by rat liver enzymes: Conversion of methylthioesters to acids by oxygenases
| Autor: | P. C. C. Feng, R. T. Solsten |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Oxygenase
Pyridines Swine Stereochemistry Health Toxicology and Mutagenesis In Vitro Techniques Toxicology Biochemistry chemistry.chemical_compound Nucleophile Animals Biotransformation Pharmacology chemistry.chemical_classification Molecular Structure Herbicides Esterases General Medicine Glutathione In vitro Rats Transformation (genetics) Enzyme Liver chemistry Oxygenases Microsome Dithiopyr NADP Conjugate |
| Zdroj: | Xenobiotica. 21:1265-1271 |
| ISSN: | 1366-5928 0049-8254 |
| DOI: | 10.3109/00498259109043201 |
| Popis: | 1. Transformation of dithiopyr by rat liver enzymes in vitro produced the corresponding monoacids as the predominant metabolites. 2. Transformations of the methylthioester functional groups in dithiopyr to the monoacids were mediated via rat liver microsomal oxygenases, and not via esterases. 3. Based on the formation of a dithiopyr-glutathione conjugate, the mechanism of monoacid formation is believed to proceed through an initial sulphur oxidation of the methylthioester group and a subsequent nucleophilic displacement reaction. |
| Databáze: | OpenAIRE |
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