Alterations in pathogenesis of experimental lymphocytic choriomeningitis caused by prepassage of the virus through heterologous host

Autor:	Gregory Shwartzman
Rok vydání:	2010
Předmět:	Immunology Viruses Immunity Immunology and Allergy Meningitis Lymphocytic Choriomeningitis
Zdroj:	Journal of immunology (Baltimore, Md. : 1950). 54(3)
ISSN:	0022-1767
Popis:	Summary Three strains of the virus of lymphocytic choriomeningitis were maintained by serial passages through mice and guinea-pigs. The substrains thus obtained possessed marked meningo-encephalotropism but differed in viscerotropic affinities. The meningo-encephalotropism was maintained by both species. Viscerotropism was lost in the mouse, but restored or imparted to the virus by the guinea-pig. Significant alterations in the pathogenesis of experimental disease were contingent upon the differences in viscerotropic affinities of the substrains.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed436704ae173b6740f140d00b16430 https://pubmed.ncbi.nlm.nih.gov/21001447 Zobrazit plný text záznamu