Jomthonic acids B and C, two new modified amino acids from Streptomyces sp
| Autor: | Yasuhiro Igarashi, Shigeru Kitani, Linkai Yu, Watanalai Panbangred, Takuya Nihira, Tsutomu Oikawa, Baatar Bayanmunkh |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.drug_class
Antibiotics Secondary metabolite Streptomyces Cell Line Mice Drug Discovery medicine Adipocytes Animals Hypoglycemic Agents Inducer Amino Acids Soil Microbiology Pharmacology chemistry.chemical_classification Adipogenesis biology Molecular Structure Drug discovery Osmolar Concentration biology.organism_classification Amino acid chemistry Biochemistry Cell culture Anti-Obesity Agents Soil microbiology medicine.drug |
| Zdroj: | The Journal of antibiotics. 67(4) |
| ISSN: | 1881-1469 |
| Popis: | Actinomycetes are recognized as the most prolific secondary metabolite producers and hence of high pharmacological and commercial interest. Until now, ca. 40% of antibiotics of natural origin were found from actinomycetes and ca. 75% of actinomycete metabolites are produced by Streptomyces spp.1 With these prominent scores, the search of new bioactive secondary metabolites from this species still remains the core of pharmaceutical discovery efforts.2 In the course of our screening program for structurally unique secondary metabolites from this richest source, we have reported jomthonic acid A (1), a new modified amino acid, as an inducer of adipocyte differentiation from the culture broth of Streptomyces sp. BB47.3 Compound 1 is an interesting modified amino acid containing rare structural units, 4-methyl-2,4-hexadienoic acid and β-methylphenyl-alanine, which have been found only in a few microbial metabolites and there are no natural products in which both units are present (Figure 1). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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