Multimarker Approach to Risk Stratification for Long-Term Mortality in Patients on Chronic Hemodialysis
| Autor: | Sadako Motoyama, Toru Aoyama, Fumihiko Kitagawa, Hiroyuki Naruse, Yukio Ozaki, Hirotake Kasuga, Yukio Yuzawa, Hideo Izawa, Junnichi Ishii, Ryuunosuke Okuyama, Daisuke Kamoi, Hideki Kawai, Hiroshi Takahashi, Midori Hasegawa, Shigeru Matsui, Takashi Muramatsu, Atsuhiro Kuno |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Disease-Free Survival Troponin T Renal Dialysis Risk Factors Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans In patient Prospective Studies Prospective cohort study Survival rate Aged business.industry Confounding Hazard ratio General Medicine Middle Aged Survival Rate C-Reactive Protein Cardiology Biomarker (medicine) Female Hemodialysis Cardiology and Cardiovascular Medicine business Biomarkers Follow-Up Studies |
| Zdroj: | Circulation Journal. 79:656-663 |
| ISSN: | 1347-4820 1346-9843 |
| Popis: | BACKGROUND We prospectively investigated the prognostic value of the combined use of cardiac troponin T (TnT), B-type natriuretic peptide (BNP), and high-sensitivity C-reactive protein (CRP) for long-term mortality in hemodialysis (HD) patients. METHODS AND RESULTS: Baseline measurements of TnT, BNP, and CRP were performed in 516 patients on chronic HD. Patients were followed up for 10 years. Using the Cox multivariate model with these 3 biomarkers as variables categorized into tertiles for mortality, a simplified score was obtained by underscoring individual biomarkers based on the adjusted hazard ratio (HR). The multimarker score was defined as the sum of these points. TnT, BNP, and CRP levels were individually independent predictors for mortality (P |
| Databáze: | OpenAIRE |
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