Immunohistochemical Study of Pepsinogen C Expression in Cutaneous Malignant Melanoma: Association with Clinicopathological Parameters
| Autor: | Francisco J. Vizoso, Quintela I, Antonio M. Merino, Serra C, Luis O. González, A Baltasar, Fernández R |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male 0301 basic medicine Cancer Research Pathology medicine.medical_specialty Skin Neoplasms Pepsinogen C Clinical Biochemistry medicine.disease_cause Pathology and Forensic Medicine Lesion 03 medical and health sciences 0302 clinical medicine Pepsin medicine Humans Melanoma Aged Aged 80 and over biology business.industry Stomach Middle Aged medicine.disease Immunohistochemistry 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Androgens biology.protein Female medicine.symptom business Carcinogenesis Immunostaining |
| Zdroj: | The International Journal of Biological Markers. 16:240-244 |
| ISSN: | 1724-6008 |
| Popis: | Background The aim of this study was to evaluate the pepsinogen C expression in malignant cutaneous melanomas and analyze its possible relationship to clinical and pathological parameters. Pepsinogen C is an aspartyl proteinase primarily involved in the digestion of proteins in the stomach and represents one of the main androgen-inducible proteins in breast cancer cells. Method Tumoral pepsinogen C expression was retrospectively analyzed in 35 paraffin-embedded tissues from patients with primary malignant cutaneous melanoma and in 10 samples from 10 benign lesions (4 dermal melanocytic nevi, 4 compound melanocytic nevi and 2 dysplastic melanocytic nevi), using immunohistochemical methods. Results The benign lesions were consistently negative for pepsinogen C, whereas 20 of the 35 malignant melanomas (57%) showed positive immunostaining for pepsinogen C. The percentage of pepsinogen C-positive tumors was significantly higher in men than in women (p=0.01) and in epithelioid melanomas than in fusocellular or mixed type melanomas (p=0.003). In addition, the percentage of pepsinogen-C positive tumors was positively and significantly correlated with lesion thickness (p=0.003), Clark's level of invasion (p=0.028) and tumor stage (pConclusion Pepsinogen C could be a new prognosticator of unfavorable outcome in cutaneous malignant melanoma. |
| Databáze: | OpenAIRE |
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