Aberrant Cortical Integration in First-Episode Psychosis During Natural Audiovisual Processing

Autor: Tuula Kieseppä, Jaana Suvisaari, Eva Rikandi, Riitta Hari, Lauri Nummenmaa, Teemu Mäntylä, Maija Lindgren, Tuukka T. Raij
Přispěvatelé: Department of Psychology and Logopedics, Medicum, Department of Psychiatry, Clinicum, HUS Psychiatry
Rok vydání: 2017
Předmět:
Male
Functional magnetic resonance imaging
Motion Pictures
Motion Perception
graph-theoretical analysis
3124 Neurology and psychiatry
Intersubject correlation
0302 clinical medicine
Parietal Lobe
Neural Pathways
Disintegration
ta515
Default mode network
Brain Mapping
medicine.diagnostic_test
05 social sciences
Cognition
Human brain
First-episode psychosis
Natural stimulation
Magnetic Resonance Imaging
working-memory
medicine.anatomical_structure
Schizophrenia
Female
Adult
Psychosis
515 Psychology
temporal receptive windows
Prefrontal Cortex
Auditory cortex
Gyrus Cinguli
050105 experimental psychology
03 medical and health sciences
Young Adult
medicine
Humans
0501 psychology and cognitive sciences
auditory-cortex
human brain
Biological Psychiatry
primary visual-cortex
Working memory
business.industry
medicine.disease
ta3124
attention
schizophrenia
Psychotic Disorders
Case-Control Studies
business
intrinsic functional connectivity
Neuroscience
030217 neurology & neurosurgery
Zdroj: Biological psychiatry. 84(9)
ISSN: 1873-2402
Popis: Background Functional magnetic resonance imaging studies of psychotic disorders have reported both hypoactivity and hyperactivity in numerous brain regions. In line with the dysconnection hypothesis, these regions include cortical integrative hub regions. However, most earlier studies focused on a single cognitive function at a time, assessed by delivering artificial stimuli to patients with chronic psychosis. Thus, it remains unresolved whether these findings are present already in early psychosis and whether they translate to real-life–like conditions that require multisensory processing and integration. Methods Scenes from the movie Alice in Wonderland (2010) were shown to 51 patients with first-episode psychosis (16 women) and 32 community-based control subjects (17 women) during 3T functional magnetic resonance imaging. We compared intersubject correlation, a measure of similarity of brain signal time courses in each voxel, between the groups. We also quantified the hubness as the number of connections each region has. Results Intersubject correlation was significantly lower in patients with first-episode psychosis than in control subjects in the medial and lateral prefrontal, cingulate, precuneal, and parietotemporal regions, including the default mode network. Regional magnitude of between-group difference in intersubject correlation was associated with the hubness. Conclusions Our findings provide novel evidence for the dysconnection hypothesis by showing that during complex real-life–like stimulation, the most prominent functional alterations in psychotic disorders relate to integrative brain functions. Presence of such abnormalities in first-episode psychosis rules out long-term effects of illness or medication. These methods can be used in further studies to map widespread hub alterations in a single functional magnetic resonance imaging session and link them to potential downstream and upstream pathways.
Databáze: OpenAIRE
Externí odkaz: