Cognition and bimanual performance in children with unilateral cerebral palsy: protocol for a multicentre, cross-sectional study
| Autor: | Iona Novak, Michael Ditchfield, Megan Thorley, Jenny Bracken, Catherine Elliott, Adrienne Harvey, Brian Hoare, Margaret Wallen, Ali Crichton |
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| Rok vydání: | 2017 |
| Předmět: |
Male
030506 rehabilitation medicine.medical_specialty Neurology Adolescent Population Neuropathology Occupational therapy lcsh:RC346-429 Cerebral palsy Upper Extremity 03 medical and health sciences Study Protocol 0302 clinical medicine Physical medicine and rehabilitation Cognition Neuropsychology medicine Humans Cognitive skill Prospective Studies education Child Upper limb Children lcsh:Neurology. Diseases of the nervous system education.field_of_study business.industry Cerebral Palsy Australia Brain Bimanual performance General Medicine medicine.disease Hand Magnetic Resonance Imaging Cross-Sectional Studies Research Design Observational study Female Neurology (clinical) 0305 other medical science business 030217 neurology & neurosurgery Psychomotor Performance |
| Zdroj: | BMC Neurology BMC Neurology, Vol 18, Iss 1, Pp 1-12 (2018) |
| ISSN: | 1471-2377 |
| Popis: | Background Motor outcomes of children with unilateral cerebral palsy are clearly documented and well understood, yet few studies describe the cognitive functioning in this population, and the associations between the two is poorly understood. Using two hands together in daily life involves complex motor and cognitive processes. Impairment in either domain may contribute to difficulties with bimanual performance. Research is yet to derive whether, and how, cognition affects a child’s ability to use their two hands to perform bimanual tasks. Methods/Design This study will use a prospective, cross-sectional multi-centre observational design. Children (aged 6–12 years) with unilateral cerebral palsy will be recruited from one of five Australian treatment centres. We will examine associations between cognition, bimanual performance and brain neuropathology (lesion type and severity) in a sample of 131 children. The primary outcomes are: Motor - the Assisting Hand Assessment; Cognitive - Executive Function; and Brain – lesion location on structural MRI. Secondary data collected will include: Motor - Box and Blocks, ABILHAND- Kids, Sword Test; Cognitive – standard neuropsychological measures of intelligence. We will use generalized linear modelling and structural equation modelling techniques to investigate relationships between bimanual performance, executive function and brain lesion location. Discussion This large multi-centre study will examine how cognition affects bimanual performance in children with unilateral cerebral palsy. First, it is anticipated that distinct relationships between bimanual performance and cognition (executive function) will be identified. Second, it is anticipated that interrelationships between bimanual performance and cognition will be associated with common underlying neuropathology. Findings have the potential to improve the specificity of existing upper limb interventions by providing more targeted treatments and influence the development of novel methods to improve both cognitive and motor outcomes in children with unilateral cerebral palsy. Trial registration ACTRN12614000631606; Date of retrospective registration 29/05/2014. |
| Databáze: | OpenAIRE |
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