SP-D loaded PLGA nanoparticles as drug delivery system for prevention and treatment of premature infant's lung diseases

Autor: Tamar Traitel, Jeffrey A. Whitsett, Riki Goldbart, Shani Attias Cohen, Joseph Kost, Paul S. Kingma
Rok vydání: 2020
Předmět:
Chemistry
Pharmaceutical
Pharmaceutical Science
02 engineering and technology
Pharmacology
030226 pharmacology & pharmacy
Cell Line
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Drug Stability
Polylactic Acid-Polyglycolic Acid Copolymer
Pulmonary surfactant
In vivo
medicine
Animals
Humans
Particle Size
Drug Carriers
Respiratory Distress Syndrome
Newborn
Lung
Respiratory distress
business.industry
Infant
Newborn
technology
industry
and agriculture
Surfactant protein D
respiratory system
Pulmonary Surfactant-Associated Protein D
021001 nanoscience & nanotechnology
Controlled release
Mice
Inbred C57BL
PLGA
medicine.anatomical_structure
chemistry
Drug delivery
Nanoparticles
0210 nano-technology
business
Hydrophobic and Hydrophilic Interactions
Infant
Premature
Zdroj: International Journal of Pharmaceutics. 585:119387
ISSN: 0378-5173
Popis: Preterm infants, particularly those who born between 23 and 28 weeks’ gestation, suffer from a very high incidence of respiratory distress syndrome (RDS) related to pulmonary immaturity and inability to make Pulmonary Surfactant (PS). These infants are supported by the use of oxygen, ventilators, and routine administration of surfactant replacement. The currently commercial surfactant replacement therapies do not contain hydrophilic surfactant proteins such as Surfactant Protein D (SP-D). These proteins have a key role in the innate lung host defense, thus the development of a sustained release vehicle that provides SP-D for long periods in preterm infants’ lungs would exploit the therapeutic potential of SP-D and other pulmonary medications. The proposed SP-D delivery system is based on nanoparticles (NPs) composed of poly (lactic acid-co-glycolic acid) (PLGA), a biodegradable, FDA approved biopolymer. The resulted NPs were spherical with high Zeta potential value, were not toxic to A-549 lungs cells, and did not induce any inflammatory response in mouse's lungs for short and long-term periods. Moreover, SP-D released from NPs showed biological activity for several days and in vivo release experiment of SP-D loaded NPs revealed that SP-D was released from NPs in mouse lungs with different NPs delivery doses.
Databáze: OpenAIRE
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