Spiral computed tomography evaluation of rabbit VX2 hepatic tumors treated with 20 kHz ultrasound and microbubbles
| Autor: | Zhi Yong Shen, Yu‑Feng Zhou, Chun Liu, Gan Lin Xia, Ming Feng Wu, Wei Zhuang, Hai‑Feng Shi |
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| Rok vydání: | 2015 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Oncogene business.industry Therapeutic effect Ultrasound H&E stain 02 engineering and technology Articles 021001 nanoscience & nanotechnology Spiral computed tomography Endothelial stem cell 03 medical and health sciences 0302 clinical medicine Coagulative necrosis Oncology 030220 oncology & carcinogenesis medicine Microbubbles 0210 nano-technology business |
| Zdroj: | Oncology letters. 14(3) |
| ISSN: | 1792-1074 |
| Popis: | The aim of the present study was to explore the therapeutic effect of 20 kHz ultrasound (US) and microbubbles (MBs) on rabbit VX2 liver tumors by spiral computed tomography (CT) scanning. A total of 16 New Zealand rabbits with hepatic VX2 tumors were divided into four groups: Control, MB, low-frequency US and US + MB. The treatment effect was evaluated by spiral CT scanning prior to, during and following treatment (at 0 weeks and the end of 1 and 2 weeks). The tumor growth rate was recorded. The specimens of VX2 tumors were collected for histological examination and transmission electron microscopy (TEM). No significant differences were observed between tumor areas measured by CT and pathology after 2-week treatment (P>0.05). The mean tumor growth rates in the control, MB, US and US + MB groups after 2 weeks of treatment were 385±21, 353±12, 302±14 and 154±9%, respectively (P |
| Databáze: | OpenAIRE |
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