The involvement of granulocytes in spontaneous regression of Walker 256 carcinoma

Autor: Rudolf J. Schaur, Morana Jaganjac, Neven Zarkovic, Marija Poljak-Blazi, Kamelija Zarkovic
Rok vydání: 2007
Předmět:
Male
Cancer Research
Pathology
medicine.medical_specialty
Time Factors
Injections
Subcutaneous
Granulocyte
Biology
Rats
Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Immune system
Immunity
Cell Movement
oxidative burst
granulocytes
Walker 256 carcinoma
anti-cancer effects
spontaneous tumour regression
sephadex
tumor-cell lysis
polymorphonuclear leukocytes
nonoxidative mechanisms
human-neutrophils
cancer-patients
cytotoxicity
therapy
phagocytosis
mice
Carcinoma
medicine
Cytotoxic T cell
Animals
Carcinoma 256
Walker
Cells
Cultured
030304 developmental biology
Respiratory Burst
0303 health sciences
Innate immune system
Melanoma
Dextrans
medicine.disease
Immunity
Innate
3. Good health
Respiratory burst
Rats
medicine.anatomical_structure
Oncology
Neoplasm Regression
Spontaneous
030220 oncology & carcinogenesis
Immunology
Granulocytes
Zdroj: Cancer letters. 260(1-2)
ISSN: 0304-3835
Popis: We described before that oxidative burst of granulocytes is cytotoxic for melanoma B16F10 and for Walker 256 carcinoma (W256). Therefore, we assumed that granulocytes could also be important mechanism of the host defence against tumour. In current study we report massive granulocyte infiltration at the site of W256 transplanted in the hind limb of Sprague– Dawley associated with spontaneous tumour regression observed for 22/25 rats (87%). Peripheral blood granulocytes of these animals were highly cytotoxic for W256 cells cultured in vitro. After the tumour disappearance the inflammatory oxidative burst of the granulocytes ended. Distraction of granulocytes from the tumour by s.c. Sephadex injection decreased the incidence of the W256 regression to only 7/25 animals (30%). These results suggest that innate immunity based on immune competent granulocytes may be the cause of well known phenomenon of spontaneous regression of W256 carcinoma.
Databáze: OpenAIRE
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