Study on the psychosocial aspects of risk-reducing salpingo-oophorectomy (RRSO) in BRCA1/2 mutation carriers in Japan: a preliminary report
| Autor: | Mizuho Kita, Yuumi Ashihara, Masami Arai, Hitoshi Okamura, Sayoko Takeuchi, Mika Shigehiro |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Risk Cancer Research medicine.medical_specialty media_common.quotation_subject Ovariectomy Menopause Premature Breast Neoplasms Anger Anxiety 03 medical and health sciences Salpingectomy 0302 clinical medicine Breast cancer Japan Hostility Internal medicine medicine Animals Humans Radiology Nuclear Medicine and imaging 030212 general & internal medicine media_common Gynecology BRCA2 Protein Ovarian Neoplasms Informed Consent business.industry BRCA1 Protein Depression Cancer General Medicine Fear Middle Aged medicine.disease Menopause Primary Prevention Distress Mood Oncology 030220 oncology & carcinogenesis Mutation Female Worry business Ovarian cancer Psychosocial Stress Psychological |
| Zdroj: | Japanese journal of clinical oncology. 46(3) |
| ISSN: | 1465-3621 |
| Popis: | Objective This study investigated the psychosocial aspects of risk-reducing salpingo-oophorectomy in Japan. Methods The subjects were 16 patients who underwent risk-reducing salpingo-oophorectomy at the Cancer Institute Hospital. Worry about cancer, emotional state and cancer-specific distress level were evaluated using a four-point Likert scale, the Profile of Mood States-Short Form and the Impact of Event Scale-Revised, respectively, before and 1 year after the surgery. In addition, the subjects were interviewed regarding their expectation for the risk-reducing surgery, the effects of the surgery, and the recovery from surgery, before the surgery and at 1, 6 and 12 months after the surgery. A t-test or Wilcoxon rank-sum test was used for the analysis, and literal analects were prepared for the interview and the answers were organized per question item using NVIVO10. Results The results revealed that the total score for worry about breast cancer and ovarian cancer (P = 0.021) as well as the Impact of Event Scale-Revised (P = 0.021) were significantly lower 1 year after surgery, compared with the values before the surgery. Regarding the preoperative expectations for the surgery, the expectation for reducing the cancer risk was the highest. The reported effects of risk-reducing salpingo-oophorectomy on life included the appearance of menopausal symptoms, a loss of motivation and poor concentration; more effects were reported at 1 year after surgery than at 6 months after surgery. Conclusions These results suggest that risk-reducing salpingo-oophorectomy can be effective for reducing worry about breast cancer and ovarian cancer and cancer-specific distress as well as contributing to a reduction in mortality from fallopian tube and ovarian related cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|