Pharmacogenetics in the Cancer Clinic: From Candidate Gene Studies to Next-Generation Sequencing
| Autor: | Hans Gelderblom, T. van der Straaten, Jan H.M. Schellens, H-J Guchelaar, Jesse J. Swen |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
Candidate gene Genetic variants Genetic Variation High-Throughput Nucleotide Sequencing Cancer Antineoplastic Agents Genomics Biology Bioinformatics medicine.disease DNA sequencing Cancer treatment Drug treatment Phenotype Pharmacogenetics Neoplasms medicine Humans Pharmacology (medical) health care economics and organizations Genome-Wide Association Study |
| Popis: | Genetics has significantly added to our understanding of variability in drug response, especially in cancer treatment. Pharmacogenetics, aimed at predicting a patient's chance for effective and safe drug treatment by interrogating germ line genetic variants, has moved from investigating a monogenetic candidate gene to examining complex phenotype-based genome-wide approaches. With the rapid advances in sequencing technologies, decline in costs, and swift turnaround times, large-scale genomic information will become available in the clinical setting, facilitating implementation of pharmacogenetics. |
| Databáze: | OpenAIRE |
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