Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus
| Autor: | Anat Bashan, Ella Zimmerman, Donna Matzov, Z. Eyal, Susanne Paukner, Miri Krupkin, Itai Wekselman, Haim Rozenberg, Ada Yonath |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Ribosomal Proteins
Staphylococcus aureus Multidisciplinary Protein Conformation medicine.drug_class Antibiotics Biology medicine.disease_cause Ribosome Microbiology chemistry.chemical_compound Antibiotic resistance PNAS Plus chemistry RNA Ribosomal Ribosomal protein Large ribosomal subunit Linezolid medicine Ribosomes Pleuromutilin |
| Zdroj: | 'Proceedings of the National Academy of Sciences of the USA ', vol: 112, pages: E5805-E5814 (2015) |
| ISSN: | 0027-8424 |
| Popis: | Significance Clinical use of the currently available antibiotics is severely compromised by the increasing resistance to them, acquired by the natural bacterial capability to manipulate their genomes. Many existing antibiotics target the fundamental process of protein biosynthesis, mainly by paralyzing the ribosome. Although antibiotics’ modes of action are similar across most eubacteria, species specificity has been detected. We determined the structures of the large ribosomal subunit from Staphylococcus aureus , a pathogenic bacterial species with a known capacity to become multiresistant, and of its complexes with known antibiotic compounds, as well as with a novel potential pleuromutilin derivative. Our new insights provide unique chemical tools for enhanced distinction between pathogens and the useful benign microbiome, as well as for suggesting novel sites for potential future antibiotics. |
| Databáze: | OpenAIRE |
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