Microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation
| Autor: | Adileh Shirmohmmadi, Reza Pourabbas, Masumeh Faramarzi, Zahra Goharfar, Atabak Kashefimehr |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Peri-implantitis
biology business.industry Bleeding on probing Dentistry Correction Minocycline biology.organism_classification Real-time polymerase chain reaction Debridement Interquartile range Enamel matrix derivative Adjunctive treatment Medicine Original Article Surgery Implant Oral Surgery medicine.symptom business Porphyromonas gingivalis Infl ammation medicine.drug |
| Zdroj: | Journal of the Korean Association of Oral and Maxillofacial Surgeons |
| ISSN: | 2234-7550 |
| Popis: | Objectives: The purpose of this study was to compare the microbial and clinical effects of mechanical debridement (MD) alone or in combination with the application of enamel matrix derivative (EMD) and sustained-release micro-spherical minocycline (MSM) for treatment of peri-implant mucosal infl ammation (PIMI). Materials and Methods: Subjects with at least one implant with PIMI were included and divided into control and two different test groups. In all three groups, MD was performed. In the MSM group, following MD, MSM was placed subgingivally around the implants. In the EMD group, after MD, EMD was placed in the sulcus around the implants. Sampling of peri-implant crevicular fl uid for microbial analysis with real-time polymerase chain reaction and recording of probing depth (PD) and bleeding on probing (BOP) were performed prior to as well as two weeks and three months after treatment. Median values and interquartile range were estimated for each variable during the various assessment intervals of the study. Results: In all groups, at two weeks and three months, the counts of Porphyromonas gingivalis decreased signifi cantly compared to baseline. Levels of P. gingivalis were signifi cantly reduced in MSM (P＜0.001) and EMD (P=0.026) groups compared to the control group. Also, clinical parameters improved signifi cantly at two weeks and three months. Reduction of PD was signifi cant in MSM (P＜0.001) and EMD (P＜0.001) groups. The decrease in BOP in the MSM, EMD, and control groups was 60%, 50%, and 20%, respectively. Conclusion: The use of MSM and EMD can be an adjunctive treatment for management of PIMI and improves clinical parameters and reduces P. gingivalis burden three months after treatment. |
| Databáze: | OpenAIRE |
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