Nuclear and mitochondrial DNA microsatellite instability in gastrointestinal stromal tumors
| Autor: | Wataru Yasui, Kazuhiro Kose, Toru Hiyama, Shinji Tanaka, Masaharu Yoshihara, Kazuaki Chayama |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Mitochondrial DNA Stromal cell Gastrointestinal Stromal Tumors Biology DNA Mitochondrial Neoplasm genetics Genomic Instability Pathology and Forensic Medicine chemistry.chemical_compound medicine Humans neoplasms Molecular Biology Aged Genetics Aged 80 and over Mesenchymal stem cell Microsatellite instability Cell Biology General Medicine DNA Neoplasm Middle Aged medicine.disease digestive system diseases chemistry Mutation Cancer research Digestive tract Female DNA Microsatellite Repeats |
| Zdroj: | Pathobiology : journal of immunopathology, molecular and cellular biology. 73(2) |
| ISSN: | 1015-2008 |
| Popis: | Objective: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Nuclear (nMSI) and mitochondrial microsatellite instability (mtMSI) play important roles in tumorigenesis in various organs. The aim of this study was to evaluate the role of nMSI and mtMSI in GISTs. Methods: Samples from 74 mesenchymal tumors were collected. nMSI and mtMSI were examined by microsatellite assay at BAT26 and D310 mononucleotide repeats in mtDNA, respectively. We compared nMSI, mtMSI and clinicopathologic features, including patient age and sex, tumor location, tumor size, presence of tumor ulceration and presence of distant metastasis, for 51 GISTs for which these data were available. Results: nMSI and mtMSI were detected in 3 (5%) and 10 (16%) of the 62 GISTs, respectively. There was no significant relationship between nMSI, mtMSI and clinicopathologic features. Conclusion: These results suggest that mtMSI may play a role, but that nMSI may play little role in the development of GISTs. |
| Databáze: | OpenAIRE |
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