| Autor: |
James I. Gray, R.I. Brooks, Albert M. Pearson, S. D. Sleight |
| Rok vydání: |
1991 |
| Předmět: |
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| Zdroj: |
Meat science. 33(1) |
| ISSN: |
0309-1740 |
| Popis: |
Two experiments were carried out to ascertain if supplementation of a semipurified diet to Swiss-ICR mice with either ascorbic acid (AA), vitamin E (Vit E) or a combination of the two would modulate the carcinogenic effects of N-nitrosopyrrolidine (NPyr) and of its probable precursors (nitrite-N02 and pyrrolidine-Pyr) in Experiment I or of NPyr in Experiment II. Results indicated that neither AA nor Vit E modulated the carcinogenic effects of NPyr or of its probable precursors (NO2 and Pyr). Results verified a previous report from our laboratory showing that NPyr increased the number of malignant tumors by some 5–8 fold over controls. There was a lower incidence of tumors in the control group on the semi-purfied diet than in the groups given NO2 and Pyr, although both treatments had a low frequency of malignant tumors ( 1 63 versus 5 72 survivors). Results support our earlier study suggesting that neither NO2 nor Pyr alone or in combination together contribute to cancer—at least in the laboratory mouse. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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