Nasal nitric oxide concentration in paranasal sinus inflammatory diseases
| Autor: | Elie Serrano, M Murris-Espin, Jean-François Arnal, Alain Didier, F Bremont, P Flores, I M Pasto Aguilla, Jacques Rami |
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| Rok vydání: | 1999 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Allergy Pathology medicine.medical_specialty Nitric Oxide Epithelium Nitric oxide chemistry.chemical_compound Nasal Polyps Immunopathology otorhinolaryngologic diseases medicine Paranasal Sinus Diseases Respiratory Hypersensitivity Humans Sinusitis Sinus (anatomy) business.industry Kartagener Syndrome Chronic sinusitis respiratory system Middle Aged medicine.disease Control subjects Paranasal sinuses medicine.anatomical_structure chemistry Chronic Disease Female Nasal Cavity business |
| Zdroj: | The European respiratory journal. 13(2) |
| ISSN: | 0903-1936 |
| Popis: | In normal upper airways, nitric oxide is generated by the paranasal sinus epithelium and then diffuses into the nasal cavities. This study examined whether or not nasal NO concentration is affected by paranasal sinus inflammatory diseases. The influence of obstruction (nasal polyposis) and/or inflammation (allergy or chronic sinusitis) of the paranasal sinuses on nasal NO concentration was evaluated in nasal allergic (n=7 patients) or nonallergic (n=20) polyposis, nonallergic chronic sinusitis (n=10) and Kartagener's syndrome (n=6) and compared with control subjects (n=42). A score of alteration of the paranasal sinus (number of altered and occluded sinuses) was determined by a computed tomography scan. The nasal NO concentration in nasal nonallergic polyposis (150+/-20 parts per billion (ppb)) was significantly decreased compared with both controls (223+/-6 ppb, p=0.01) and polyposis with allergy (272+/-28 ppb, p |
| Databáze: | OpenAIRE |
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